小剂量多塞平联合莫沙必利治疗功能性消化不良的临床观察

目的探讨莫沙必利联合抗抑郁药多塞平治疗功能性消化不良的疗效及安全性。方法将127例功能性消化不良患者随机分为试验组（64例）和对照组（63例）。试验组给予莫沙必利5mg每日3次,饭前30min口服,多塞平12.5mg睡前口服;对照组单用莫沙必利,疗程均为8周。分别于治疗前及治疗第1、2、4、8周末进行疗效评价。结果试验组治疗1、8周末总有效率分别为39.06%和82.81%。对照组治疗1、8周末总有效率分别为19.04%和36.50%,2组比较有显著性差异。结论莫沙必利联合多塞平治疗功能性消化不良具有良好的临床疗效。

Mosapride combined with doxepin in functional dyspepsia

Objective To explore the efficacy and safety of mosapride combined with doxepin in functional dyspepsia. Methods 127 patients with functional dyspepsia were randomly divided into experimental （n=64） and control （n=63） group.Patients took mosapride 5 mg/d Tid 30 minutes before meals and doxepin 12.5 mg/d before sleep, and the controls only took orally mosapride for 8 weeks. The efficacy was assessed before treatment and at the ends of 1^st ,2^nd ,4^th and 8^th week during treatment. Results At the ends of the 1^st and 8^th week, total efficacy rates were 39.06% and 82.81% in the experimental group,and 19.04% and 36.50% of the control group respectively.The difference was statistically significant. Conclusions Combination of mosapride and doxepin has satisfactory efficacy in functional dyspepsia.