竹节参总皂苷对高血脂模型小鼠的影响作用

目的:研究竹节参总皂苷降血脂的药理活性。方法:腹腔注射75%蛋黄生理盐水溶液0.02mL.g-1建立小鼠高血脂动物模型。随机分为空白对照组、高脂模型组、2个阳性对照组(包括血脂康组及辛伐他汀组)和2个试验组(Z1高剂量组及Z1低剂量组)。空白对照组给予生理盐水,高脂模型组给予蛋黄乳溶液和生理盐水,阳性对照组和试验组以CMC-Na混悬,配成混悬药液样品。测定给药后动物血浆中TG、TC、LDL-C、HDL-C的mmol.L-1浓度。结果:阳性对照组和试验组各项指标与模型组比较,差异均有显著性。结论:竹节参总皂苷具有一定的降血脂的作用,并呈现量效关系。

Experimental Study on the Antihyperlipidemia Effect of the Total Rhizoma Panacis Japonica Saponins

Objective： To study if the total rhizoma panacis japonica saponins could influence high blood lipid level and to provide evidence in developing new drugs on antihyperlipidemia.Methods： Hyperlipidemia mice model was established by celiac injection of 75% egg-yolk emulsion.Then the animals were administrated with samples comprising equal saponins of different doses from Panax japonicus C.A.Mey.The total cholesterol（TC）,triglyceride（TG）,low density lipoprotein-cholesterol（LDL-C） and high density lipoprotein-cholesterol（HDL-C） in serum were measured.Results：In comparison with control groups,TC,TG,LDL-C levels in the total saponins in Panax japonicus C.A.Mey were significantly decreased;HDL-C levels were significantly increased.Conclusion： Both the two extracts show notable antihyperlipidemia effect in serum in mice,but the high doses results were better than the low doses.