| 脑内移植基因修饰细胞治疗帕金森病 |
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| 引用本文： | 唐镇生 应其龙. 脑内移植基因修饰细胞治疗帕金森病[J]. 中华外科杂志, 1997, 35(1): 10-12 |
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| 作者姓名： | 唐镇生 应其龙 |
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| 作者单位： | 上海华山医院 |
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| 摘 要： | 由于供体来源困难，脑移植治疗帕金森病在是的应用受到限制。作者将酪氨酸羟化酶基因导入ＮＩＨ－３Ｔ３细胞，这种经ＴＨ基因修饰的细胞，呈ＴＨ免疫组化阳性反应，并能产生左旋多巴。作者认为，本实验结果具有潜在的临床应用价值。
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| 关 键 词： | 震颤性麻痹 基因治疗 胎组织移植 基因转移 |
Intracerebral transplantation of genetically modified cells for Parkinson''s disease] |
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| Z Tang,Q Ying,L Peng. Intracerebral transplantation of genetically modified cells for Parkinson''s disease][J]. Chinese Journal of Surgery, 1997, 35(1): 10-12 |
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| Authors: | Z Tang Q Ying L Peng |
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| Affiliation: | Department of Neurosurgery, Huashan Hospital, Shanghai. |
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| Abstract: | The clinical application of brain transplantation for treating Parkinson's disease (PD) is limited because it is difficult to obtain ideal donor cells. In this study, the tyrosine hydroxylase (TH) gene was introduced into NIH-3T3 cell line and the genetically modified cells reacted positively with TH antiserum and released L-dopa. These cells were implanted into the striatum of PD rats. 3,6,9,12 days after implantation, the average rate of the abnormal rotational behavior recovery was 52.6%, 68.4%, 63.2%, 44.7%, respectively. This result is considered to be potential for further clinical application. |
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