胆石中脂肪酸存在的意义及其发生机制的探讨

作者利用高效液相色谱分析（ＨＰＬＣ）方法,根据确立的提取胆石中脂肪酸的程序,对１８例中国人和３７例日本人胆石进行了分析。发现胆色素类结石的总脂肪酸、游离脂肪酸含量均明显多于黑色石或胆固醇类结石。游离饱和／总饱和脂肪酸的比值,肝内色素类结石最高,肝外色素类结石次之,较后两类结石都有显著性差异。作者认为胆色素类结石形成过程中,胆汁中磷脂在磷脂酶的作用下分解出游离脂肪酸参与结石的形成,并且磷脂酶Ａ１的作用较Ａ２更为重要。

The role and mechanism of fatty acids in gallstones

18 Chinese cases and 37 Japanese cases of gallstones were analyzed according to the procedure of extracting fatty acids in the gallstone. High perforamance liquid chromatography (HPLC), showed that the contents of total fatty acid and free fatty acid in pigment stones were obviously higher than those in black stone or cholesterol stone. The ratio free saturated to total saturated fatty acid is the highest in intrahepatic pigment stone and less in extrahepatic pigment stone, which significantly differs from the latter two kinds of stones. This may indicate that phospholipid in the bile catablizes into free fatty acids involved in the formation of stone under the action of phospholipase in the course of pigment stone formation. The action of phosphoipase A1 is more important than phospholipase A2.