胎脑黑质移植物在帕金森病大鼠纹状体内长期存活（TH免疫组化及印…

运用细胞免疫组织化学技术和免疫印迹试验手段,观察了胎脑黑质多巴胺神经元移植到ＰＤ大鼠纹状体内存活、发育、生长的变化规律,发现移植物在宿主脑组织内有“发育延迟”现象,随着移植时间延长,移植物多巴胺神经元能够对宿主神经建立神经再支配作用,并且,这种神经再支配作用更有利于移植物有效地发挥功能。

Long-term survival of fetal substantia nigra grafts in striatum of PD rats: an observation of tyrosine hydroxylase immunohistochemistry and western blot]

By using immunohistochemistry and Western blot, we observed the varied patterns of survival, development and growth of dopaminergic neurons after intrastriatal transplantation of fetal substantia nigra. There was a phenomenon of "developmental delay" of grafts in the host. As the time of transplantation went on, the grafted dopaminergic neurons could reinnervate the host neurons. The observation reveals that the reinnervation between graft and host is more beneficial to the functioning of the grafts.