胃癌术前选择性动脉化疗对组织和细胞结构的影响

为了解术前选择性动脉化疗后胃癌组织和细胞结构的变化，作者对８２例ＴＮＭⅠ～Ⅳ期的胃癌患者术前以常规剂量的ＦＡＭ方案进行治疗，对其术后标本进行了观察、研究。结果显示：（１）５６．１％病例出现了因治疗而发生的组织坏死。与血供不良所引起的自然坏死不同，这种坏死灶均位于血管周围。（２）癌细胞出现核固缩、碎裂，细胞浆凝固、坏死，细胞间质出现炎细胞浸润、炎症反应、水肿和纤维增生，血管出现内膜增生和血栓形成。这些变化多以中度为主，重度及无变化者较少。作者认为，作为胃癌的综合治疗方法，术前常规剂量的选择性动脉化疗值得推荐。

Influence of preoperative on gastric cancer tissues and cells

We studied how gastric cancer tissues and cells changed as a result of preoperative chemotherapy. 82 patients with gastric cancer in TNM I-IV stage underwent preoperative selective vascular chemotherapy with routine quantity of FAM. Histological analysis of their postoperative specimens revealed the following results. (1) Cancer tissues necrosed in 56.1% patients. These necroses, due to the chemotherapy, were located around vascular vessels. (2) Cancer cells were found to change with karyopyknosis, karyorrhexis, coagulation and necrosis of cytoplasm. There were invasion of lymphocytes, inflammation edema, and fibroelastosis around cancer cells as well. Changes were also observed in vessels with proliferous intima and thrombus. Most of these changes were grade 2. This paper summarises that preoperative vascular chemotherapy can bring about evident histological and cell changes in different types of gastric cancer. This kind of chemotherapy is recommended as one of integrative treatments to gastric cancer.