重组生长激素对严重感染后蛋白代谢影响的实验研究

本文旨在探讨重组生长激素对腹腔严重感染后蛋白质代谢的影响及其作用机制。作者以大鼠讯肠结扎穿孔复制严重感染模，并将其分为治疗组和感组，分别于术后给予生长激素和生理盐水，进行观察研究。

Influence of recombinant growth hormone on protein metabolism during severe infection: an animal experiment]

We observed the influence of recombinant growth hormone (rGH) on protein metabolism during sepsis and found its mechanisms. Cecal ligation and puncture were choosen to duplicate the severe infection model. Animals of therapy group received rGH 1 U/kg/d after CLP operation, while sepsis group received normal saline. rGH accelerated regaining of the positive nitrogen equilibrium, improved plasma albumin level. rGH accelerated the recovery of intestinal mucosa glutaminase activity, preserved the normal structure of intestinal mucosa, reduced the portal venous endotoxin level and venous TNF level. rGH improved the albumin synthesis of isolated hepatocytes, and inhibited the expression of albumin mRNA level during severe infection. We conelude that rGH preserves the normal structure and function of intestinal mucosa during sepsis, and reduces gut origin hypermetabolism reactions. Moreover, rGH improves the synthesis of protein.