三种屏障膜体内埋植的组织学变化

目的：评价消旋聚乳酸表面特性对牙周引导组织再生（GTR）的适用性。方法：将国产消旋聚乳酸（PDLLA），膨体聚四氟乙烯（ePTFE)，胶原（COL）膜埋植于大鼠皮下，分别于术后2，4，8周取出，以扫描电镜对3种膜的体内标本表面作电镜观察比较。结果：以PDLIA用作牙周GTR屏障膜的适用性为最好，初始时PDLLA表面光滑无孔呈均质；2周时出现小突，凹陷或小孔；4周时表面类圆孔隙明显增多，相连成片，孔中有细胞进入，PDLIA表面的大量类圆孔隙使材料呈树皮状，有大量胶原基质沉积和大量的皱缩细胞镶嵌，结论：国产PDLLA膜的生物相容性良好，符合牙周GTR的基本要求。具有用于牙周GTR的潜力。

Surface Characteristic of Domestic Poly -DL-Lactic Acid Membrane for Periodontal Guided Tissue Regeneration

OBJECTIVE: To evaluate the surface characteristic of domestic poly-DL-lactic acid membrane for periodontal guided tissue regeneration. METHODS: Three guided tissue regeneration membranes (PDLLA, ePTFE, COL)were implanted in rats subcutaneously, then they were removed 2,4,8 weeks after surgery for examination under scanning electron microscope. The membranes in vitro served as control. RESULTS: The surface of PDLLA membrane was characterized by unorganized smooth film structure. After 2 weeks implanted subcutaneously, its surface became rough with numerous oval micropores in it. These oval micropores were 5 microm in size.The micropores increased gradually in size and number 4, 8 weeks after implantation,there were many shindle shaped cells inlayed. CONCLUSION: Domestic Poly-DL-lactic acid membrane exhibits excellent biocompatibility,which meets the criterion for GTR.