蜀羊泉凝胶大鼠皮肤长期毒性实验研究

目的:观察和测定蜀羊泉凝胶长期连续经皮肤给药对实验动物大鼠的长期毒性。方法:用蜀羊泉凝胶以高低两组剂量,分别经大鼠完整及破损皮肤每天给药1次,连续90 d,观察大鼠一般性状,检测主要血液学指标、生化指标以及主要脏器病理组织学的变化。结果:主要血液学指标、生化指标、主要脏器重量系数等均属正常范围,与空白对照组比较无统计学差异;解剖主要脏器未见病理性改变。结论:蜀羊泉凝胶长期连续经皮肤给药对试验大鼠没有毒性反应,说明在临床剂量下使用是安全的,为临床安全用药提供了实验依据。

Study of Long-term Toxicity on Applying Solanum lyratum on Rat Skin

Objective: To observe the long-term toxicity of rats which we had applied Solanum lyratum Thunb gel on their skins daily for 90 days.Methods: We had applied high and low doses of Solanum lyratum Thunb gel one time each day on healthy and punctured rats skins respectively for 90 days.The rats' characters were observed,and their blood routines,blood biochemistry index,anatomic and pathologic changes of their major organs were also detected.Results: Rats' characters had no change,the results of all detections were normal.There was no significant difference between test groups and control group.Rats' major organs had no change in anatomy and pathology.Conclusion: No long-term toxic reaction can be found in the test of rats applied Solanum lyratum Thunb gel on their skins for a long term.It proves that it is safe using the normal dose of this gel on the skin in clinic.