枯氏细胞活性对疟原虫子孢子的拘留和对其穿越肝血窦壁的作用

本文综述了枯氏细胞—肝内巨噬细胞—的生理活性对拘留疟原虫子孢子及对其杀伤或转运子孢子越过肝血窦壁的作用。巨噬细胞的吞噬活性对拘留血流中子孢子起重要作用;肝组织中拘留子孢子数量远较脾、肺中的多。一般情况下,枯氏细胞吞噬活性愈强,愈有利于子孢子入侵,其杀伤活性愈强,愈有利于阻止子孢子入侵。当用制剂使枯氏细胞杀伤活性大大增强后,则吞噬活性愈强,被杀伤的子孢子也愈多,从而入侵的子孢子也愈少。

Effects of Kupffer''''s cell activity on traping of plasmodial sporozoites and on their passing through hepatic sinus walls

The effects of Kupffer's cells on the traping or killing of the plasmodial sporozoites and on the transporting of them through the hepatic sinus walls into the Disse's space were summarized.The phagocytosis of Kupffer's cells plays an important role to trap the sporozoites and the ability to trap sporozoites is higher in the liver than in the lungs and the spleen.In general,the stronger the phagocytosis of the Kupffer's cells,the more advantageous to the invasion of sporozoites;the higher the biocidal activity of Kupffer's cells,the more advantageous for the host to prevent the sporozoites from invading.When the biocidal activity of the Kupffer's cells is enhanced by certain drug agents,more sporozoites can be phagocytized and killed and less amounts of sporozoites will invade the host's red cells.