| 石菖蒲对小鼠脑组织氨基酸类神经递质的影响 |
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| 引用本文： | 唐洪梅,席萍,吴敏,蔡庆群. 石菖蒲对小鼠脑组织氨基酸类神经递质的影响[J]. 中药新药与临床药理, 2004, 15(5): 310-311 |
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| 作者姓名： | 唐洪梅 席萍 吴敏 蔡庆群 |
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| 作者单位： | 广州中医药大学第一附属医院,广州,510405 |
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| 基金项目： | 广东省中医药管理局科研项目，广州中医药大学校科研和教改项目 |
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| 摘 要： | 目的研究石菖蒲对小鼠脑组织氨基酸类神经递质的影响,分析作用机制.方法 石菖蒲不同部位提取物灌胃,用高效液相色谱法测定小鼠脑组织氨基酸类神经递质的含量.结果石菖蒲挥发油、水提液、去油水煎液可使大鼠谷氨酸( Glu)水平显著降低,挥发油、水提液使天门冬氨酸( Asp)含量降低,挥发油组的牛磺酸( Tau)含量也有较明显降低.结论 石菖蒲可降低小鼠脑组织兴奋性氨基酸的含量,对脑细胞有保护作用.
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| 关 键 词： | 石菖蒲 氨基酸 神经递质 小鼠 |
| 文章编号： | 1003-9783(2004)05-0310-02 |
| 修稿时间： | 2004-03-10 |
Effects of Rhizoma Acori Tatarinowii on Amino Acids Neurotransmitter in Mice Brain |
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| TANG Hongmei,XI Ping,WU Min,CAI Qingqun. Effects of Rhizoma Acori Tatarinowii on Amino Acids Neurotransmitter in Mice Brain[J]. Traditional Chinese Drug Research & Clinical Pharmacology, 2004, 15(5): 310-311 |
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| Authors: | TANG Hongmei XI Ping WU Min CAI Qingqun |
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| Abstract: | Objective To study the effects of Rhizoma Acori Tatarinowii (RAT) on amino acids neurotransmitter in mice brain and to explore its mechanisms. Methods After treated by different parts of RAT,the cerebral contents of the amino acids neurotransmitter in rats were detected by high performance liquid chromatography (HPLC) Results Volatile oil, fluid extract and defatted decoction of RAT could significantly lower cerebral glutamic acid level. Volatile oil and fluid extract decreased the content of aspartic acid, and volatile oil could also reduce the taurine content in brain tissue. Conclusion RAT can lower the contents of excitatory amino acids(EAA ) and has protective effect on the brain. |
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| Keywords: | Rhizoma Acori tatarinowii Amino acid Neurotransmitter Mouse |
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