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| 止消通脉宁对糖尿病大鼠肾组织糖化终产物受体mRNA表达的调节 | |
| 引用本文： | 高彦彬,唐代屹,吕仁和,黄启福,李德昌.止消通脉宁对糖尿病大鼠肾组织糖化终产物受体mRNA表达的调节[J].北京中医药大学学报,2001,24(4):14-15. |
| 作者姓名： | 高彦彬 唐代屹 吕仁和 黄启福 李德昌 |
| 作者单位： | 1. 北京中医药大学东方医院 2. 北京协和医科大学 3. 北京中医药大学基础医学院 4. 北京大学生命科学学院 |
| 基金项目： | 国家“九五”攻关课题 (No .96 90 6 0 9 0 8) |
| 摘 要： | 观察止消通脉宁对糖尿病大鼠肾组织糖化终产物受体 (RAGE)mRNA表达的影响。以链脲佐菌素 (STZ)诱导的糖尿病大鼠为模型 ,采用逆转录聚合酶链式反应 (RT PCR) ,检测止消通脉宁治疗 12周糖尿病大鼠肾组织RAGEmRNA水平。结果显示糖尿病大鼠肾皮质糖化终产物(AGEs)含量、RAGEmRNA表达均高于正常大鼠 (P <0 0 1) ,止消通脉宁可降低糖尿病大鼠肾皮质AGEs含量 ,下调肾皮质RAGEmRNA过度表达 (P <0 0 1)。说明止消通脉宁可调节糖尿病大鼠肾组织RAGEmRNA的异常表达 |
| 关 键 词： | 止消通脉宁 糖尿病 糖化终产物 受体 大鼠 |
| 修稿时间： | 2000年9月28日 |
Regulative Effects of Zhixiaotongmaining on the mRNA Expression of Renal AGE Receptor in Diabetic Rats |
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| Gao Yanbin,Tang Daiyi.Regulative Effects of Zhixiaotongmaining on the mRNA Expression of Renal AGE Receptor in Diabetic Rats[J].Journal of Beijing University of Traditional Chinese Medicine,2001,24(4):14-15. | |
| Authors: | Gao Yanbin Tang Daiyi |
| Abstract: | In order to study the regulative effects of Zhixiaotongmaining on the mRNA expression of renal AGE receptor in diabetic rats, streptozotocin was used to induce rat diabetic model and RT PCR method was used to detect the level of renal mRNA expression of AGE receptor in the diabetic rats treated with Zhixiaotongmaining for 12 weeks. The results showed that the content of renocortical AGEs and the level of the mRNA expression of renocortical AGE receptor in the diabetic rats were higher than those in the normal rats ( P <0.01); and Zhixiaotongmaining could decrease the content of renocortical AGEs and the overdue mRNA expression of renocortical AGE receptor in the diabetic rats ( P <0.01). The results suggest that Zhixiaotongmaining can regulate the abnormal mRNA expression of renal AGE receptor in the diabetic rats. |
| Keywords: | Zhixiaotongmaining AGEs AGE Receptor RAGE Rat |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |