Norplant皮下埋植避孕法对肝功能及糖、脂、蛋白质的影响

<正> Norplant皮下埋植避孕法为一新型、女用、长效避孕法。避孕效果好,持续使用率高。它由每支内装36 mg左旋18甲基炔诺酮结晶的6枚硅橡胶管组成,总剂量为216 mg。每管长34 mm,外径为2.4 mm。

Changes in liver function and three metabolites before and after subdermal implantation with Norplant]

Since the introduction of Norplant into China in 1984, numerous studies on its clinical effectiveness and acceptability have been reported. This paper reports the comparison of liver function indicators before and after Norplant implantation which aimed at studying the longterm safety of Norplant. 36 parous women with the mean age of 28.7 who were nonsmokers and were not breast feeding were recruited into the study. Clinical examinations were conducted before and at 6, 12, and 24 months after implantation. Changes in body weight and blood pressure and in metabolism of sugar, fat, and protein were found statistically significant using t tests and chi-square tests, but they were all within the normal range. Blood tests showed nonsignificant changes in liver function indicators. The study results suggested that Norplant implantation does not affect liver function. The indicators examined fluctuated around the normal range which suggested that Norplant is a safe method of contraception. But as the number of cases in the study is small, further investigation is necessary.