双气囊内镜检查对小肠溃疡病变的诊断研究

目的 研究双气囊内镜(DBE)检查对小肠溃疡病变的诊断价值.方法 统计2003年9月到2007年12月广州南方医院DBE检查发现的小肠单纯溃疡而内镜活检显示为"小肠溃疡"或"慢性炎症"者的资料.结果 符合以上条件者62例,其中男48例,女14例,年龄10～71岁,平均43.9岁.临床主诉为消化道出血38例(61.3%)、腹痛16例(25.8%)、腹胀5例(8.1%)、消瘦2例(3.2%)、腹泻1例(1.6%).DBE诊断为克罗恩病53例(85.5%)、药物性溃疡4例(6.5%)、慢性非特异性炎症2例(3.2%)、淋巴瘤2例(3.2%)、结核1例(1.6%).62例内镜活检常规病理全部为"慢性炎症".其中32例行手术治疗(51.6%),在DBE诊断为克罗恩病的30例中,手术后诊断为克罗恩病22例(3例合并癌变)、淋巴瘤4例、白塞病3例、小肠结核1例,DBE确诊率73.3%;DBE诊断的1例小肠结核和1例淋巴瘤,手术后诊断均为克罗恩病.62例小肠溃疡病变DBE总的确诊率为68.8%(22/32),误诊率达31.2%(10/32).结论 对小肠溃疡病变的定性诊断,DBE结合常规活检也不是特异的,常规病理结合免疫组化技术有可能提高诊断的准确率,当内科治疗效果不好时,适时外科手术对其诊断和治疗都是有益的.

Double balloon endoscopy in diagnosis of ulcerative lesions in small intestine

Objective To evaluate the use of double balloon endoscopy(DBE) in diagnosis of ulcerative lesions in small intestine.Methods Data of patients diagnosed as small intestinal ulcer under DBE during September 2003 and December 2007 at Nanfang Hospital were analyzed retrospectively.Results Ulcer in small intestine was detected by DBE in a total of 62 patients,including 48 males and 14 females,aging from 10 to 71 years old( mean 43.9 yr).The main clinical manifestations consisted of small intestinal hemorrhage(38/62,61.3%),abdominal pain(16/62,25.8%),abdominal distention(5/62,8.1%),loss of weight(2/62,3.2%),and diarrhea(1/62,1.6%).The ulcers were diagnosed endoscopically as Crohn's disease(CD) in 53 cases(85.5%),drug induced lesions in 4(6.5%),nonspecific chronic inflammation in 2(3.2%),lymphoma in 2(3.2%) and tuberculosis in 1(1.6%).They were all microscopically diagnosed as chronic inflammation.Of the 62 patients,32(51.6%) underwent surgery.In 30 cases of CD diagnosed by DBE,22 were confirmed by post-surgery pathology(malignant cells were found in 3),while in the other 8 cases,4 were diagnosed as lymphoma,3 as Behcet's disease and 1 as tuberculosis.Meanwhile,the 1 case of tuberculosis and 1 lymphoma diagnosed by DBE were confirmed as CD after operation.The overall accurate diagnosis rate of small intestinal ulcerative lesions by DBE was 68.8%(22/32).Conclusion DBE is valuable in diagnosis of ulcerative lesions in small intestine,but surgery should be included into consideration to confirm the diagnosis when necessary.