| 乳腺癌干细胞与临床及其靶向治疗前景 |
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| 引用本文： | 张俊峰,房林. 乳腺癌干细胞与临床及其靶向治疗前景[J]. 同济大学学报(医学版), 2013, 34(1): 108-110 |
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| 作者姓名： | 张俊峰 房林 |
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| 作者单位： | 同济大学附属第十人民医院普外科 |
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| 基金项目： | 上海市科委基金(STCSM10411964700) |
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| 摘 要： | 肿瘤干细胞理论认为肿瘤起源于小部分具有干细胞特性的肿瘤细胞。肿瘤干细胞（cancer stem cells，CSCs）具有自我更新、不对称分裂、放化疗耐受及致瘤性和转移潜能。因此，癌症的治疗必然要包含针对CSCs的靶向治疗。本文综述了乳腺癌干细胞与其临床转移及放、化疗耐受的关系和潜在的靶向治疗研究。
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| 关 键 词： | 乳腺肿瘤 干细胞 转移 放化疗耐受 靶向治疗 |
Clinical implications of breast cancer stem cells and their application in targeting therapy |
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| ZHANG Jun-feng and FANG Lin. Clinical implications of breast cancer stem cells and their application in targeting therapy[J]. Journal of Tongji University(Medical Science), 2013, 34(1): 108-110 |
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| Authors: | ZHANG Jun-feng and FANG Lin |
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| Affiliation: | (Dept.of General Surgery,Tenth People’s Hospital,Tongji University,Shanghai 200072,China) |
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| Abstract: | The cancer stem cell theory suggests that cancer develops from a subset of tumor cells that possess characteristics of stem cells. These cancer stem cells （CSCs） possess the properties of self- renewal, asymmetric cell division, tumourigenicity, metastatic potential and resistance to chemo-and radiation-therapy. So it is necessary to effectively target CSCs in cancer therapy. This paper reviews the links of breast CSCs（BCSCs） with cancer metastasis and chemo-and radio-resistance,also discusses the potential application of BCSCs-targeted therapy. |
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| Keywords: | BCSCs metastasis chemo-and radio-resistance targeted therapy |
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