| N,N′-亚烷基双(取代苯酚)氨基乙酸的合成及对放射性核素钍-234的促排效果 |
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| 引用本文： | 孙梅贞,朱佩萼,唐诚,陈爱芬,沈彬源.N,N′-亚烷基双(取代苯酚)氨基乙酸的合成及对放射性核素钍-234的促排效果[J].药学学报,1990(7). |
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| 作者姓名： | 孙梅贞 朱佩萼 唐诚 陈爱芬 沈彬源 |
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| 作者单位： | 上海医科大学放射医学研究所，上海医科大学放射医学研究所，上海医科大学放射医学研究所，上海医科大学放射医学研究所，上海医科大学放射医学研究所 上海 200032，上海 200032，上海 200032，上海 200032，上海 200032 |
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| 摘 要： | 本文报道合成的16个N,N′-亚烷基双(取代苯酚)氨基乙酸除化合物3,4外对放射性钍-234的加速排出均有较好的效果。其中有二个化合物促排效果达到70％以上,根据动物实验结果初步探讨了构效关系。
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| 关 键 词： | 放射性核素 钍-234 络合剂 |
SYNTHESIS OF N,N '-ALKYLENE-BIS-(SUBSTITUTEDPHENOL)GLYCINE FOR REMOVAL OF RADIO-ACTINIDES IN RATS |
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| MZ Sun,PE Zhu,C Tang,AF Chen and BY Shen.SYNTHESIS OF N,N '-ALKYLENE-BIS-(SUBSTITUTEDPHENOL)GLYCINE FOR REMOVAL OF RADIO-ACTINIDES IN RATS[J].Acta Pharmaceutica Sinica,1990(7). |
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| Authors: | MZ Sun PE Zhu C Tang AF Chen and BY Shen |
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| Abstract: | The synthesis of 16 compounds of N, N'-alkylene-bis (substituted phenol) glycine is reported. They showed good effects on the removal of redinuclide thorium-234 from rats, except compound 3 and compound 4. Two of them can remove more than 70% of injected thorium. The relationship between structure and effects of these compounds was discussed. |
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| Keywords: | Radionuclide Thorium-234 Chelating agent |
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