Clinical Features of Severe Influenza A (H1N1) Virus Infection |
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Authors: | Yinghu Chen Shiqiang Shang Yongmin Tang ChenMei Zhang Meiqin Tong Yuwen Dai |
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Institution: | 1. Division of Infection Disease, Zhejiang Key Laboratory for Neonatal Disease, Children’s Hospital of Zhejiang University Medical College, Hangzhou, China 2. 57# Zhugan xiang Road, Xiacheng District, Hangzhou, 310003, China
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Abstract: | Objective To highlight the clinical presentations of influenza A (H1N1) infection, for early diagnosis and recognition by the pediatricians. Methods In this retrospective study, the medical records of inpatients with influenza A (H1N1) infection between November 1, 2009 and May 31, 2011were reviewed. Results Eighty pediatric in-patients with median age 41.9 mo were studied. ARDS (11/80), pneumothorax (8/80), pleural effusion (7/80) and encephalopathy (7/80) were the most frequent complications. Six of 11 ARDS patients died;all of them were under 5 y. The median days of viral shedding was 11.4 d. Slight increase of Il-6, Il-10 and TNF-γ were revealed in some cases. Conclusions During late stage of pandemic wave, the majority of patients were young children. Children with severe Influenza A (H1N1) are prone to develop complications, and die from ARDS. If influenza-like illness is accompanied by neurologic signs, influenza A (H1N1) virus infection should be considered. The viral shedding in children is longer than in adults. |
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