复方皂矾丸防治吉西他滨加顺铂方案化疗所致血小板下降的临床观察

目的：观察复方皂矾丸防治吉西他滨加顺铂方案化疗所致血小板下降的临床疗效。方法：将39例患者随机分为治疗组20例及对照组19例,两组均采取吉西他滨加顺铂方案化疗1个周期（吉西他滨1.0g·m^-2,静脉滴注,d1、d8;顺铂25mg·m^-2,静脉滴注,d1-3）。治疗组化疗的同时口服复方皂矾丸1.6g（每日3次,连续服用8d）至化疗结束,对照组单纯使用化疗方案。化疗14d后比较两组患者血小板抑制程度及血小板总数的变化。结果：化疗14d后,治疗组血小板抑制程度低于对照组、血小板总数高于对照组,两组间比较差异具有统计学意义（P〈0.05）。结论：复方皂矾丸能减轻吉西他滨加顺铂方案化疗所致血小板下降。

Effect observation of complex Zaofan pill on preventing platelet depression caused by gemcitabine and cisplatin combination chemotherapy

Objective：To observe the effect of complex Zaofan pill on preventing platelet depression caused by gemcitabine and cisplatin（GP） combination chemotherapy.Methods：Thirty-nine cancer patients receiving GP combination chemotherapy for 1 cycle were divided into treatment group（20 cases） and control group（19 cases）.Two groups were all intravenously treated with gemcitabine 1.0 g·m^-2 for the fi rst and eighth day and cisplatin 25 mg·m^-2 for the first three days.At the same time,the treatment group was also orally treated with complex Zaofan pill 1.6 g three times a day for 8 days.While the control group was treated with GP chemotherapy only.The occurrence of platelet depression and the total platelet count were evaluated after the chemotherapy for 14 days.Results：The extent of platelet depression was lower in treatment group than in control group and the total platelet count was higher in treatment group than in control group after the chemotherapy for 14 days,which showed signifi cant difference between two groups（P〈0.05）.Conclusion：Complex Zaofan pill can lighten the platelet depression caused by GP combination chemotherapy.