泰宁等7种抗菌药物对临床常见致病菌抗菌活性的比较

本实验采取琼脂平板稀释法测定了泰宁等７种抗菌药物对５种２ｌ５株临床常见致病菌的最低抑菌浓度（ＭＩＣ），并统计了敏感率，结果表明７种抗菌药物对大多数受试菌均显示了较高的抗菌活性，其中泰宁的抗菌活性最强。金黄色葡萄球菌、变形杆菌、大肠埃希氏菌、肺炎克雷白氏菌对泰宁的敏感率达９７．６～１００％；１７．０２％的绿脓假单胞菌耐药，４．２６—１２．７７％绿脓假单胞菌和１株肺炎克雷白氏菌对泰宁和其他抗菌药物呈现部分交叉耐药性，而ＣＰＦＸ与其他抗菌药物对不同受试菌呈现２．３８～１９．０５％的交叉耐药率，该结果提示对其他β－内酰胺类抗菌药物耐药的致病菌引起的严重感染，可考虑选用泰宁，但ＣＰＦＸ的选用还应根据药敏试验决定。

Comparision of Antibacterial Activity of IMP/CS and other 6 Anti- microbial Agents Against Clinical lsolates

The minimum inhibitory concentration(MIC) of 7 antimicrobialagents against 215strains of 5 species of clinical isolates were determined by using agar disk dilution method and thesusceptible rates were analyzed. The results showed that all 7 antimicrobial agents exhibited highactivity against most of isolates tested, Among them the IMP/CS had best activity; the susceptiblepercentage of S. aureus, Proteus sp,E. coli,K. pneumonia to the IMP/CS were high up to97.6 100%;only 17.02%strains of ps aeruginosa were resistant to IMP/CS;2-6 strains of Psaeruginosa and l strains of K. pneumonia were crossresistant to IMP/CS and other antimicrobialagents. The crossresistant percentage of the isolates tested to CPFX and other antimicrobialagents were 2.38-19.05%. The results suggested that IMP/CS may be used in treatment of seriousinfections caused by clinical isolates resistant to other B-lactam antimicrobial agents; the CPFXshould be selected according to the susceptibility test.