铜陵地区细菌耐药性监测与分析

目的　研究铜陵地区临床分离菌对抗菌药物的耐药特征。方法　收集 2 0 0 0年 1月 1日至 2 0 0 1年12月 31日在铜陵地区 3所综合性医院临床分离的致病菌。采用Kirby -Bauer法进行药敏试验 ,按照美国临床实验标准委员会 2 0 0 0年判断标准分析结果。结果　 2年共收集致病菌 2 4 5 9株 ,包括革兰阳性球菌 911株(37.0 % ) ,革兰阴性杆菌 14 75株 (6 0 .0 % ) ;致病菌以表皮葡萄球菌、大肠埃希氏菌、铜绿假单胞菌、金黄色葡萄球菌、克雷伯氏菌属多见。有 79.9%的凝固酶阴性葡萄球菌和 5 0 .3%的金黄色葡萄球菌耐苯唑西林 ,对其它药物耐药率亦高。铜绿假单胞菌、克雷伯氏菌属、肠杆菌属、不动杆菌对第三代头孢菌素和氟喹诺酮类的耐药性均有显著增高。结论　合理用药和控制滥用是当务之急

Surveillance of bacterial resistance In Tong Ling district

Objective To analyze the drug resistance of clinical isolates collected in the period from January 1, 2000 to December 31, 2001in Tong Ling area. Methods Bacterial susceptibility test of clinical isolates collected from three Tong Ling hospitals were performed using Kirby-Bauer method and the results were analyzed according to NCCLS (2000). Results Total of 2459 clinical isolates, including 911 strains (37.0%) of Gram positive cocci and 1475 strains (60.0%) of Gram negative baccilli. S.epidermidis, E.coli, P.aeruginosa, S.aureus and Klebsiella were the main microorganisms. 50.3% of S.aureus and 79.9% of the coagulase negative staphylococci (CNS) were resistant to oxacillin and other antimicrobials. Resistant rates of Pseudomonas aeruginosa, Klebsiella spp, Enterobacter spp and Acinetobacter spp against third generation cephalosporins and fluoroquinolones increased markedly. Conclusions Rational use of antimicrobial agents and restricting the misuse of antibiotics were urgent needs.