Protection of rat hippocampus against ischemic neuronal damage by pretreatment with sublethal ischemia |
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Authors: | Yong Liu Hiroyuki Kato Naoki Nakata Kyuya Kogure |
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Institution: | Department of Neurology, Tohoku University School of Medicine, Sendai, Japan. |
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Abstract: | We examined whether preconditioning with sublethal ischemia protects against neuronal damage following subsequent lethal ischemic insults. Forebrain ischemia for 3 min in Wistar rats increased heat shock protein-70 immunoreactivity in the hippocampal CA1 subfield but produced no neuronal damage. Preconditioning with 3 min of ischemia followed by 3 days of reperfusion protected against hippocampal CA1 neuronal damage following 6 and 8 min of ischemia but not damage after 10 min of ischemia. The result strongly suggests that stress response induced by sublethal ischemia protects against ischemic brain damage. |
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Keywords: | Cerebral ischemia Hippocampus Ischemic brain damage Heat shock protein Tolerance Stress response Rat |
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