腺苷负荷脑灌注显像安全性研究

目的 评价腺苷负荷脑血流灌注显像的安全性.方法 以腺苷负荷作为介入手段,按照常规腺苷负荷心肌灌注显像的方式,对80例脑病患者进行隔日法静息和负荷脑血流灌注显像.观察、记录患者在负荷过程前、中、后的主观、客观不良反应.结果 80例患者中没有发现因不良反应而提前终止或延长负荷显像的病例.有46例(58%)出现不同程度轻微不良反应.其主要症状包括头晕20例(25%)、心悸12例(15%)、低血压1例(1%)、气短7例(9%)、发热4例(5%)、出汗3例(4%)、恶心4例(5%)、皮肤潮红6例(8%)、胸部不适19例(24%)、腹部不适6例(8%)、味觉异常3例(4%)、口干1例(1%).只有1例出现ST段轻度压低心电图改变.结论 腺苷负荷脑血流灌注显像安全性好,不良反应轻微.

Safety of adenosine in stress cerebral perfusion imaging

Objective To evaluate the safety of adenosine as pharmacological stress agents in stress cerebral perfusion imaging. Methods Eighty patients under investigation for suspected cerebral vessel disease were recruited. Each had a resting seen and a stress scan on different days. The adenosine stress protocol was as same as the protocol used in adenosine stress myocardial perfusion imaging. Subjective and objective side-effects were investigated during pharmacological stress procedure. Results All patients completed the 6 min infusion protocol without premature termination on safety criteria or due to intolerable symptoms. 46 patients had mild side effects. 20 patients (25%) had dizziness, 12 patients (15%) had palpitation, 1 patient (1%) was hypotensive, 7 patients (9%) had dyspnoea, 4 patients (5%) felt hot, 3 patients (4%) had sweat, 4 patients (5%) had nausea, 6 patients (8%) had flushing, 19 patients (24%) had chest pain, 6 patients (8%) had abdomen pain, 3 patients (4%) had abnormal taste and 1 patient (1%) were thirsty. Transient ST change occurred in only 1 patient. Conclusion Adenosine stress cerebral perfusion imaging is a safe diagnostic method with mild side effects.