克拉霉素对慢性阻塞性肺疾病急性期患者痰液的影响

目的 通过口服克拉霉素,评测其对慢性阻塞性肺疾病(COPD)急性期患者痰液理化性质的影响.方法 将38例COPD急性期轻度发作患者分别给予口服克拉霉素和阿莫西林或青霉素V钾片,服用后第7天、第14天分别取患者痰液进行理化性质测试比较.结果 克拉霉素组在第7天和第14天所取痰液,均较对照组在痰液日排量、干/湿重、黏度、中性粒细胞弹力酶差异有统计学意义(P＜0.05).结论 口服克拉霉素除有明确的抗炎作用外,其对慢性炎症所致的气道黏液高分泌也有较明显的抑制作用,能达到一定程度的标本兼治.

Effects of clarithromycin on sputum of patients with chronic obstructive pulmonary disease

Objective To investigate the influence of clarithromycin on phlegm characteristics in the patients with acute period of chronic obstructive pulmonary disease(COPD).Methods Thirty-eight subjects with COPD in acute period were treated by clarithromycin and amoxicillin or penicilin.The sputum were collected after 7d and 14d.The phlegm characteristics were assayed and compared.Results The sputum collected after 7d and 14d in clarithromycin group had statistical difference in daily excrcted quantity,dry/wet weight,mucosity and expression of membrane-bounded neutrophils elastase compared with control group(P<0.05).Conclusion The clarithromycin can evidently inhibit the mucous hypersecretion caused by chronic airway inflammation except anti-inflammatory effect.So it can achieve simultaneous treatment of the cause and symptoms to a certain degree.