| BCL-2、CK20、CD10、AR表达在基底细胞癌和毛母细胞瘤鉴别诊断中的意义 |
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| 引用本文： | 何春燕,金玉兰,杨冬梅,刘红刚.BCL-2、CK20、CD10、AR表达在基底细胞癌和毛母细胞瘤鉴别诊断中的意义[J].临床与实验病理学杂志,2011,27(10). |
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| 作者姓名： | 何春燕 金玉兰 杨冬梅 刘红刚 |
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| 作者单位： | 首都医科大学附属北京同仁医院病理科,100730 |
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| 基金项目： | 北京市卫生系统高层次卫生技术人才培养计划 |
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| 摘 要： | 目的 观察BCL-2、CK20、CD10、AR在基底细胞癌(basal cell carcinoma,BCC)和毛母细胞瘤(trichoblastoma,TB)中表达的不同,以提高它们在两者诊断和鉴别诊断中的作用.方法 对确诊的32例BCC和8例TB石蜡包埋标本行BCL-2、CK20、CD10、AR免疫组化染色,观察它们在肿瘤细胞及其周围间质中的表达.结果 32例BCC中BCL-2肿瘤上皮弥漫阳性表达30例,阴性2例;CK20均为阴性;CD10肿瘤上皮部分表达23例,阴性9例,肿瘤间质阳性4例,阴性28例;AR阳性表达7例.8例TB中BCL-2上皮部分均阳性表达,CK20散在阳性6例,阴性2例,CD10部分上皮阳性4例,阴性4例,间质阳性3例,阴性5例;AR均为阴性.统计结果,BCL-2、CK20表达差异有显著性意义(P＜0.01),AR、CD10差异无显著性意义.结论 BCL-2弥漫强阳性、CK20阴性支持诊断BCC,反之支持诊断TB.
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| 关 键 词： | 基底细胞癌 毛母细胞瘤 病理学 免疫组织化学 |
BCL-2,CK20,CD10 and AR expression in basal cell carcinoma and trichoblastoma |
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| HE Chun-yan,JIN Yu-lan,YANG Dong-mei,LIU Hong-gang.BCL-2,CK20,CD10 and AR expression in basal cell carcinoma and trichoblastoma[J].Chinese Journal of Clinical and Experimental Pathology,2011,27(10). |
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| Authors: | HE Chun-yan JIN Yu-lan YANG Dong-mei LIU Hong-gang |
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| Institution: | HE Chun-yan,JIN Yu-lan,YANG Dong-mei,LIU Hong-gang(Department of Pathology,Affiliated Tongren Hospital,Capital Medical University,Beijing 100730,China) |
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| Abstract: | Purpose To observe the different expression of BCL-2,CK20,CD10,androgen receptor(AR) in basal cell carcinoma(BCC) and trichoblastoma(TB),and to improve diagnosis and differential diagnosis.Methods 32 cases of basal cell carcinoma and 8 cases of trichoblastoma were studied by using of immunohistochemical staining for BCL-2,CK20,CD10 and AR,The expression of BCL-2,CK20,CD10 and AR in tumor cells and surrounding stromal were observed.Results 30 cases of BCC were BCL-2 diffusely positive in the tumor cells;CK20... |
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| Keywords: | basal cell carcinoma trichoblastoma pathology immunohistochemistry |
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