序贯疗法治疗幽门螺杆菌感染患者疗效观察

目的:观察序贯疗法治疗幽门螺杆菌(Hp)感染患者的疗效。方法:经胃镜检查确诊的慢性胃炎或消化性溃疡且Hp阳性患者82例,随机分为治疗组和对照组。治疗组(42例)方案为前5d奥美拉唑+阿莫西林,后5d奥美拉唑+克拉霉素+替硝唑;对照组(40例)三联疗法为奥美拉唑+阿莫西林+克拉霉素,疗程7d。结果:治疗组Hp根除率92.86%,对照组Hp根除率75.00%,两组比较差异有统计学意义(P<0.05)。结论:以奥美拉唑、阿莫西林、克拉霉素、替硝唑组成的10d序贯疗法治疗Hp感染较7d三联疗法有更高的根除率,可提高临床疗效。

The Clinical Observation of Sequential Therapy for Patients with Helicobacter Pylori Infection

Objective：To study the effects of sequential therapy for H.pylori eradication.Methods： 82 patients with Hp positive chronic gastritis and peptic ulcer were randomly divided into two groups.42 patients were treated with Omeprazole,amoxillin at first five days,Omeprazole,clarithromycin and tinidazole at the second five days.The control group（40 patients）were treated with Omeprazole,amoxillin and clarithromycin for seven days.Results：The eradication rate of 10d sequential therapy was 92.86%,and that of control group was 75.00%.The difference between two groups was significant（P0.05）.Conclusion：The sequential therapy is more effective and better treatment for H.pylori eradication.