芦荟多糖对氟尿嘧啶抗小鼠荷瘤H_(22)作用的影响

目的:研究不同剂量芦荟多糖对氟尿嘧啶抗小鼠荷瘤H22的影响。方法:建立小鼠荷瘤H22移植实体型及腹水型模型,观察不同剂量芦荟多糖及芦荟多糖协同氟尿嘧啶对小鼠荷瘤H22疗效的影响;同时通过检测荷瘤H22移植小鼠的外周血细胞数、碳粒廓清、迟发型变态反应、血清凝集素和IL-2及IF-γ水平的变化,观察其毒性变化。结果:不同剂量芦荟多糖对氟尿嘧啶治疗小鼠荷瘤H22实体型及腹水型均有协同作用,但低剂量芦荟多糖组的协同作用更强。同时芦荟多糖可以剂量依赖性对抗氟尿嘧啶引起的荷瘤H22移植小鼠外周血细胞数降低,阻止其碳粒廓清、凝集素生成,使荷瘤H22移植小鼠迟发型变态反应能力降低、升高其血清IL-2及IF-γ水平。结论:芦荟多糖对氟尿嘧啶治疗小鼠荷瘤H22有增强疗效的作用,可以降低氟尿嘧啶对机体的毒性。

Effects of Aloe Polysaccharide on Treatment of Fluorouracil for Murine Sarcoma H22

Objective：To study the effects of different dose about aloe polysaccharide on treatment of fluorouracil for murine sarcoma H22.Methods：The effects of different dose about aloe polysaccharide on treatment of fluorouracil for murine sarcoma H22were tested by using transplanted solid and ascetic sarcoma H22model,meanwhile,the toxicity caused by fluorouracil was examined by peripheral blood cells counting,clearance rate of charcoal particles,delayed type hypersensitivity,serum content of agglutinin and IL-2 as well as IF-γ.Results：Different dose of aloe polysaccharide had a synergistic antitumor activity with fluorouracil in both solid and ascitic tumor models and the low-dose group was better.Meanwhile,it protected sarcoma mice treated with fluorouracil against decreasing in peripheral blood cell counts,clearance rate of charcoal particles,and delayed type hypersensitivity,serum content of agglutinin and IL-2 as well as IF-γ in a dose-dependent effect.Conclusion：Aloe polysaccharide has an enhanced therapeutic potential and a decreased toxicity on treatment of fluorouracil for murine sarcoma H22.