| 肝细胞癌中ZHX2、NF-YA及AFP表达的相关关系 |
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| 引用本文： | 胡少为,杨海峰,王智园,袁丽娜,文剑明.肝细胞癌中ZHX2、NF-YA及AFP表达的相关关系[J].临床与实验病理学杂志,2011,27(10). |
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| 作者姓名： | 胡少为 杨海峰 王智园 袁丽娜 文剑明 |
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| 作者单位： | 1. 广东省中医院病理科,广州,510120
2. 中山大学附属第一医院病理科,广州,510080 |
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| 摘 要： | 目的 检测肝细胞癌(hepatocellular carcinoma,HCC)组织中ZHX2、NF-YA及AFP mRNA和蛋白表达的相关关系.方法 采用RT-PCR及免疫组织化学方法检测HCC组织中ZHX2、NF-YA及AFP mRNA和蛋白的表达情况.结果 ZHX2 mRNA在AFP mRNA阴性的25例HCC组织中的表达率为52.0%,明显高于AFP mRNA阳性组织中的表达率(26.3%,P=0.038),ZHX2 mRNA与AFP mRNA表达呈负相关(OR=0.33);NF-YA mRNA与ZHX2 mRNA表达呈正相关(OR=31.429),而与AFP mRNA表达呈负相关关系(OR=0.308).AFP蛋白阴性的142例HCC组织中,ZHX2蛋白的表达率为23.9%,明显高于在AFP蛋白阳性组织中的表达率(12.8%,P=0.034);HCC组织中ZHX2蛋白与AFP蛋白表达呈负相关(P=0.018,r=-0.153).NF-YA蛋白在HCC组织中与ZHX2蛋白表达呈正相关(P=0.000,r=0.371),与AFP蛋白表达呈负相关(P=0.000,r=-0.497).结论 联合检测AFP和ZHX2蛋白将提高HCC的诊断率;ZHX2可能是通过NF-YA来调控AFP的表达.
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| 关 键 词： | 肝肿瘤 肝细胞癌 甲胎蛋白 |
Relations between ZHX2, NF-YA and AFP expression in HCC tissues |
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| HU Shao-wei,YANG Hai-feng,WANG Zhi-yuan,YUAN Li-na,WEN Jian-ming.Relations between ZHX2, NF-YA and AFP expression in HCC tissues[J].Chinese Journal of Clinical and Experimental Pathology,2011,27(10). |
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| Authors: | HU Shao-wei YANG Hai-feng WANG Zhi-yuan YUAN Li-na WEN Jian-ming |
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| Institution: | HU Shao-wei1,YANG Hai-feng1,WANG Zhi-yuan1,YUAN Li-na1,WEN Jian-ming2(1Department of Pathology,Guangdong Hospital of Chinese Traditional Medicine,Guangzhou 510120,China,2Department of Pathology,First Affiliated Hospital,Sun Yat-sen University,Guangzhou 510080,China) |
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| Abstract: | Purpose To study the relations between ZHX2,NF-YA and AFP expression in HCC tissues.Methods We detected mRNA and protein expression of ZHX2,NF-YA and AFP in HCC tissues by RT-PCR and immunohistochemistry.Results ZHX2 mRNA expression rate(52.0%) in HCC tissues without AFP mRNA expression was significantly higher than that(26.3%) with AFP mRNA expression(P=0.038).There was a negative relationship between ZHX2 and AFP mRNA expression(OR=0.33).In addition,NF-YA mRNA expression was positively correlated with ZHX... |
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| Keywords: | ZHX2 NF-YA |
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