他克莫司软膏联合短程地塞米松软膏治疗面部脂溢性皮炎临床观察

目的探讨他克莫司软膏联合短程地塞米松软膏治疗面部脂溢性皮炎的疗效和安全性。方法 71例面部脂溢性皮炎患者均在治疗前3d联合用药,即先涂0.05%地塞米松软膏,30min后涂0.1%他克莫司软膏,早晚各1次;3d后停地塞米松软膏,继续用他克莫司软膏,皮损消退后,每周2～3次涂他克莫司维持治疗。结果治疗1,2和4周时,皮损总平均积分分别为5.83±3.72,1.78±1.71和0.68±1.12,均比治疗前(14.79±6.52)有明显下降,差异有统计学意义(P<0.01);研究者和患者评价的有效率分别为98.59%和97.18%。除4例患者在用药后出现局部轻度灼热感,持续用药3d后自行缓解外,未观察到其他不良反应。结论他克莫司软膏联合短程地塞米松软膏治疗面部脂溢性皮炎安全有效。

Combination of Tacrolimus Ointment and Short-term Use of Dexamethasone Acetate Ointment for Facial Seborrheic Dermatitis

Objective To investigate the efficacy and safety of combination therapy of 0.1% tacrolimus ointment and short-term use of 0.05% dexamethasone acetate ointment for facial seborrheic dermatitis.Methods Seventy one patients were enrolled.All patients were advised to use 0.05% dexamethasone acetate ointment firstly and then to apply 0.1% tacrolimus ointment half an hour later,twice daily,during the first three days.In the following days,dexamethasone acetate ointment was discontinued and only tacrolimus ointmen...