脑复康对大鼠局灶性脑缺血引起的脑水肿及神经功能变化的影响

目的探讨脑复康(吡拉西坦)对局灶性脑缺血引起的脑水肿及神经学行为的影响.方法阻断大鼠一侧大脑中动脉造成局灶性脑缺血模型.分别通过舌下静脉输注不同剂量的脑复康注射液及甘露醇注射液,观察各组动物在阻断大脑中动脉24h后,动物神经功能、脑梗塞体积及脑组织含水量的变化,并与假手术组及对照组进行比较分析.结果阻断大鼠一侧大脑中动脉引起了动物神经功能的明显变化及阻断侧大脑半球的严重水肿.脑复康注射液剂量依赖性地降低动物的脑梗塞体积及阻断侧大脑半球的含水量,改善其神经功能,1000 mg/kg脑复康注射液的降低脑水含量及脑梗塞体积、改善神经功能的作用与同剂量的甘露醇效果相当.结论较大(250 mg/kg以上)剂量的脑复康注射液对局灶性缺血的脑组织有明显的保护作用.

Effects of Piracetam on Cerebral Edema and Change in Neurological Function Induced by Cerebral Ischemia in Rats

Objective To explore the effects of piracetam on cerebral edema and change in neurological function induced by cerebral ischemia. Methods The model of cerebral ischemia was established by the unilateral middle cerebral artery occlusion in the rats. The mannitol injection and piracetam injection of different doses were infused into hypoglossal vein respectively in the different group 30 minutes after the middle cerebral artery occlusion. The change in the neurological function, cerebral water content and volume of cerebral infarction were determined 24 hours after cerebral ischemia. Results The disturbance of neurological function and severe cerebral edema were produced by the unilateral middle cerebral artery occlusion in rats. The decreases in the cerebral water content, and volume of cerebral infarction, and improvement in neurological function produced by piracetam injection were dose-dependent in the rats with cerebral ischemia. The decreases in the cerebral water content and volume of the cerebral infarction, and improvement in the neurological function produced by 1 000mg/kg piracetam injection were similar to that produced by 1 000mg/kg mannitol injection. Conclusion The piracetam injection of 750mg/kg or more than 750mg/kg can decrease damage to the brain due to ischemia.