| 中国南海黑乳海参共附生真菌Phialemonium sp.次生代谢产物的鉴定 |
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| 引用本文： | 王旭东,孙鹏,许东啸,汤华,刘宝姝,张文. 中国南海黑乳海参共附生真菌Phialemonium sp.次生代谢产物的鉴定[J]. 第二军医大学学报, 2014, 35(9): 988-991 |
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| 作者姓名： | 王旭东 孙鹏 许东啸 汤华 刘宝姝 张文 |
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| 作者单位： | 解放军第425医院药械科,第二军医大学药学院海洋药物研究中心,第二军医大学药学院海洋药物研究中心,第二军医大学药学院海洋药物研究中心,第二军医大学药学院海洋药物研究中心,第二军医大学药学院海洋药物研究中心 |
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| 基金项目： | ] 国家自然科学基金(30873200, 41176125,81202453),上海浦江人才计划(PJ2008)．海南省自然科学基金(811223),三亚市医疗卫生科技创新项目(YW1228)Supported by NSFC (30873200,41176125), Shanghai Pujiang Talent Program (PJ2008),Hainan NSF (811223) and Sanya medicinal innovative project (YW1228)． |
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| 摘 要： | ［］ 目的 对中国南海黑乳海参的共附生单胞瓶霉属真菌(Phialemonium sp.)的次生代谢产物进行研究。 方法 运用硅胶柱色谱、Sephadex LH-20凝胶柱色谱、高效液相色谱等分离手段对真菌Phialemonium sp.的乙酸乙酯提取物进行分离纯化,利用现代波谱技术结合文献报道进行结构鉴定。 结果 共分离得到2个缩酚酸环醚化合物,emeguisin A和aspergillusidone C。结论 本研究是对黑乳海参共附生真菌Phialemonium sp.次生代谢产物的首次报道,2个缩酚酸环醚成分均为首次从该种真菌中分离得到。
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| 关 键 词： | 黑乳海参；共附生真菌；单胞瓶霉属；缩酚酸环醚 |
| 收稿时间： | 2014-07-01 |
| 修稿时间： | 2014-09-11 |
Identification of secondary metabolites of the fungus Phialemonium sp. associated with the South China Sea cucumber Holothuria nobilis Selenka |
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| WANG Xu-dong,SUN Peng,XU Dong-xiao,TANG Hu,LIU Bao-shu and ZHANG Wen. Identification of secondary metabolites of the fungus Phialemonium sp. associated with the South China Sea cucumber Holothuria nobilis Selenka[J]. Former Academic Journal of Second Military Medical University, 2014, 35(9): 988-991 |
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| Authors: | WANG Xu-dong SUN Peng XU Dong-xiao TANG Hu LIU Bao-shu ZHANG Wen |
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| Affiliation: | Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University |
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| Abstract: | Objective To investigate the secondary metabolites of the Phialemonium sp. fungus associated with the South China Sea cucumber Holothuria nobilis Selenka. Methods The EtOAc extract of Phialemonium sp. was purified by repeated column chromatography on silica gel, Sephadex LH-20, and high-performance liquid chromatography (HPLC). Structural determination of the isolated compounds was achieved by spectroscopic analysis and by comparison with previously reported data. Results Two depsidones were isolated and their structures were determined as : emeguisin A (1) and aspergillusidone C (2), respectively. Conclusion This is the first report on the secondary metabolites of Phialemonium sp. associated with the sea cucumber H. nobilis Selenka. The two depsidones are reported for the first time from the Phialemonium sp. fungus strain. |
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| Keywords: | Holothuria nobilis Selenka sea cucumber associated fungus Phialemonium sp. depsidone |
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