中药有效成分在血-眼屏障通透性及促透方法的研究进展

血-眼屏障( blood-eye barrier,BEB)是机体维持眼内环境稳定的重要结构之一,但同时也是药物治疗内眼疾病的主要制约因素。传统中药能调节人体生理功能,且毒副作用较低,对治疗内眼疾病有独特的优势。本文结合国内外文献报道,对BEB的特性作简要概括,并重点综述中药及其有效成分在 BEB 通透性及促透作用的研究进展。

Current progress in the permeability and its enhancement approches for TCM active ingredients across blood-eye barrier

Blood-eye barrier(BEB)is one of the most important structures of organism to maintain homeostasis of the eye. However, it is the major constraint for the medication of intraocular diseases. Traditional Chinese medicines have distinctive advantages for the treatment of intraocular diseases, which can be used to regulate the physiological function of human body with low toxicity. In this article, we have briefly summarized the feature of BEB, with the domestic and foreign literatures combined, and mainly reviewed current progress in the field of study on the permeability of traditional Chinese medicines and effective components in BEB and promoting methods.