慢性泪囊炎致病菌分布及药物敏感性分析

目的：分析慢性泪囊炎致病菌和药物敏感性的现状，为临床合理用药提供依据。
　　方法：对171例慢性泪囊炎患者的泪囊分泌物取样，做病原菌培养鉴定及药物敏感试验。针对结果分析慢性泪囊炎致病菌菌株的检出率，慢性泪囊炎致病菌菌种种类，慢性泪囊炎的主要致病菌，大多数致病菌对何种药物敏感。结果：慢性泪囊炎的致病菌检出率为76.61%(131例)。革兰阳性球菌构成慢性泪囊炎的主要致病菌，占72.52%(95例)，其中人葡萄球菌占27.48%(36例)，表皮葡萄球菌占16.79%(22例)，草绿色链球菌占12.98%(17例)。大多数致病菌对头孢哌酮/舒巴坦、妥布霉素、庆大霉素、左氧氟沙星敏感，其中革兰阳性球菌中对头孢哌酮/舒巴坦、庆大霉素、妥布霉素最为敏感，革兰阴性杆菌对头孢哌酮/舒巴坦、妥布霉素、左氧氟沙星最为敏感。
　　结论：人葡萄球菌成为慢性泪囊炎的主要致病菌，妥布霉素可作为治疗慢性泪囊炎的首选局部用抗生素。

Pathogens distribution and drug sensitivity of chronic dacryocystitis

AIM: To analyze the pathogens and drug sensitivity of chronic dacryocystitis in order to provide evidence for clinical drug use.

METHODS: Lacrimal secretion of 171 cases with chronic dacryocystitis was sampled for pathogenic bacteria culture identification and drug sensitivity test. Based on the results, the isolation rate of pathogens strains, the pathogens kind of chronic dacryoeystitis, main pathogens of chronic dacryocystitis, and sensitive drug for pathogens were analyzed.

RESULTS: The isolation rate of pathogens strains was 76.61%(131 cases). The pathogens constituting the chronic dacryocystitis were predominantly gram-positive coccus,the percentage was 72.52%(95 cases), among which staphylococcus hominis occupied 27.48%(36 cases), staphylococcus epidermidis 16.79%(22 cases), streptococcus viridans 12.98%(17 cases). The majority of these bacteria were sensitive to cefoperazone-sulbactam, tobramycin, gentamicin and levofloxacin. For gram-positive coccus, cefoperazone-sulbactam, gentamicin and tobramycin were the most sensitive drug. For gram-negative bacilli, cefoperazone-sulbactam, tobramycin and levofloxacin were most sensitive drug.

CONCLUSION: Staphylococcus hominis is the main pathogen of chronic dacryocystitis, tobramycin can be used as the first choice for local treatment of chronic dacryocystitis.