Characterization of two non-locus of enterocyte effacement-encoded type III-translocated effectors, NleC and NleD, in attaching and effacing pathogens |
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| Authors: | Marchés Olivier Wiles Siouxsie Dziva Francis La Ragione Roberto M Schüller Stephanie Best Angus Phillips Alan D Hartland Elizabeth L Woodward Martin J Stevens Mark P Frankel Gad |
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| Affiliation: | CMMI, Flowers Building, Imperial College London, London SW7 2AZ, United Kingdom. |
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| Abstract: | Intestinal colonization by enteropathogenic and enterohemorrhagic Escherichia coli requires the locus of enterocyte effacement-encoded type III secretion system. We report that NleC and NleD are translocated into host cells via this system. Deletion mutants induced attaching and effacing lesions in vitro, while infection of calves or lambs showed that neither gene was required for colonization. |
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