高血压患者血、尿β_2-微球蛋白的测定对其肾功能改变的临床意义

目的:探讨高血压患者的早期肾脏损害与血、尿β2-微球蛋白的关系。方法:选择高血压组58例,正常组32例,用放射免疫法测定血、尿β2-微球蛋白,并对两组间血、尿β2-微球蛋白进行相关分析。结果:高血压组血β2-微球蛋白水平为(2.679±1.274)mg/L,较正常对照组(1.725±0.547)mg/L明显升高,有显著性差异(P<0.05);且高血压组尿β2-微球蛋白水平为(137.2±130.0)μg/L,较正常对照组(52.0±32.0)μg/L明显升高,有显著性差异(P<0.05)。结论:高血压患者早期肾脏损害与血、尿β2-微球蛋白有密切的关系,血、尿β2-微球蛋白可作为高血压患者肾功能改变的一项敏感指标。

Clinical significance of β2-microglobulin of blood and urine to renal function of hypertension

Objective:To investigate the relationship between the early renal damage and blood and urine β2-microglobulin(β2-MG) in hypertensive patients.Methods:β2-microglobulin levels in blood and urine in 58 hypertensive patients and 32 normal controls were determined with radioimmunoassay and the correlation between the two the groups was compared and analyzed.Results:Plasma level of β2-microglobulin in hypertensive patients(2.679±1.274) mg/L was significantly higher than that in the normal controls(1.725±0.547) mg/L(P<0.05).The urine level of β2-microglobulin in hypertensive patients(137.2±130.0) μg/L was also significantly higher than that in the normal controls(52.0±32.0) μg/L(P<0.05).Conclusion:The early renal damage of hypertension patients is closely associated with the β2-microglobulin in blood and urine.Measurement of β2-microglobulin in blood and urine can be used as a sensitive indicator for the diagnosis of renal function of hypertension.