| 排除AZF微缺失为反复自然流产的原因 |
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| 引用本文： | 卢洪涌,崔英霞,夏欣一,史轶超,杨滨,邵永,戈一峰,姚兵,李晓军,黄宇烽. 排除AZF微缺失为反复自然流产的原因[J]. 中华男科学杂志, 2008, 14(12): 1099-1102 |
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| 作者姓名： | 卢洪涌 崔英霞 夏欣一 史轶超 杨滨 邵永 戈一峰 姚兵 李晓军 黄宇烽 |
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| 作者单位： | 南京军区南京总医院解放军临床检验医学研究所,江苏,南京,210002 |
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| 摘 要： | 目的:探讨Y染色体上AZF微缺失和反复自然流产之间的关系。方法:收集26份男性流产胚胎的绒毛样本,51份配偶反复流产的男性血液,分别提取基因组DNA,选取位于Yq11.2上AZFa、AZFb和AZFc的12个STS位点,对流产胚胎绒毛样本和血液样本进行AZF的多重PCR检测。结果:流产胚胎的26份样本中没有发现AZF的微缺失,51份血液样本中也没有发现AZF的微缺失。结论:排除AZF微缺失为反复自然流产的原因。
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| 关 键 词： | 无精子症因子 反复自然流产 多重PCR |
AZF Microdeletions Are Not Related with Recurrent Spontaneous Abortion |
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| LU Hong-yong,CUI Ying-xia,XIA Xin-yi,SHI Yi-chao,YANG Bin,SHAO Yong,GE Yi-feng,YAO Bing,LI Xiao-jun,HUANG Yu-feng. AZF Microdeletions Are Not Related with Recurrent Spontaneous Abortion[J]. National journal of andrology, 2008, 14(12): 1099-1102 |
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| Authors: | LU Hong-yong CUI Ying-xia XIA Xin-yi SHI Yi-chao YANG Bin SHAO Yong GE Yi-feng YAO Bing LI Xiao-jun HUANG Yu-feng |
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| Affiliation: | LU Hong-yong,CUI Ying-xia,XIA Xin-yi,SHI Yi-chao,YANG Bin,SHAO Yong,GE Yi-feng,YAO Bing,LI Xiao-jun,HUANG Yu-feng PLA Institute of Clinical Laboratory Medicine,Nanjing General Hospital of Nanjing Military Region,Nanjing,Jiangsu 210002,China |
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| Abstract: | Objective:To study the relationship between azoospermia factor(AZF) microdeletions of the Y-chromosome and recurrent spontaneous abortion.Methods:We collected 26 chorionic villus samples from abortive male embryos and 51 blood samples from the husbands whose wives had recurrent spontaneous abortion,extracted genomic DNA from the samples and detected 12 STSs in the AZFa,AZFb and AZFc regions of Yq11.2 by amplification multiplex PCR.Result:AZF microdeletions were found neither in the chorionic villus samples ... |
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| Keywords: | azoospermia factor recurrent spontaneous abortion multiplex PCR |
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