| 胶原微球作为药物载体的研究进展 |
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| 引用本文： | 石婧圆,陈燕忠,吕竹芬.胶原微球作为药物载体的研究进展[J].中国现代药物应用,2010,4(5):229-231. |
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| 作者姓名： | 石婧圆 陈燕忠 吕竹芬 |
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| 作者单位： | 广东药学院药物研究所,510006 |
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| 摘 要： | 近年来，微粒给药系统的发展为大分子药物靶向及缓控释给药提供更多的方法，但对药物载体的要求也越来越高。胶原因其良好的生物相容性、生物可降解性及极低的免疫原性成为药物载体材料研究的新热点。本文对胶原作为药物载体的研究进展进行了综述，包括胶原微球、胶原包衣微球及胶原复合材料微球的研究。
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| 关 键 词： | 胶原微球 药物载体 |
Collagen Microparticles in Drug Delivery |
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| SHI Jing-yuan,CHEN Yan-zhong,LV Zhu-fe.Collagen Microparticles in Drug Delivery[J].Chinese Journal of Modern Drug Application,2010,4(5):229-231. |
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| Authors: | SHI Jing-yuan CHEN Yan-zhong LV Zhu-fe |
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| Institution: | . (Institute of Phar- maceutical Sciences, Guangdong College of Pharmacy, Guangzhou 510006, China) |
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| Abstract: | Targeting delivery and controlled release devices for macromolecular drugs delivery make a big challenge to microparticle drug delivery system, especially the drug carriers. Collagen is an interesting natural material for the preparation of microparticles. The attractiveness of collagen rests on its high biocompatibility and low immunogenicity. This article highlights collagen microparticles＇ present status as a carrier in drug delivery, including ： collagen-coated microspheres, the preparation of collagen microparticles and collagen composites. |
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| Keywords: | Collagen microparticles Drug carrier |
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