70例急性脑梗死患者血清OX—LDL及S—100B蛋白检测分析

目的讨论急性脑梗死患者血清OX-LDL、S-100B蛋白的表达规律及临床意义。方法用ELISA法检测70例急性脑梗死患者发病24h内及40例正常时照组血清OX-LDL、S-100B蛋白含量。结果急性脑梗死患者血清0X—LDL、S-100B蛋白含量均显著高于正常对照组（P〈0．01），它们分别为（615．9±197．6）μg／L、（0．884±0．594）μg／L；正常对照组为（158．6±68．4）μg／L、（0．065±0．02）μg／L。急性脑梗死患者血清OX-LDL、S-100B蛋白含量呈正相关（r=0．536，P〈0．01），且含量高低与病情严重程度有密切关系。结论血清OX-LDL、S-100B蛋白的含量可作为急性脑梗死病情监测的指标。

Detection of serum OX-LDL and S-100B in 70 patients with acute cerebral infarction

Objective To study the expression regularity of serum OX-LDL,S-100B and to explore its clinical significance in acute cerebral infarction. Methods Using enzyme-linked immunosobent assays we examined the levels of serum OX-LDL, S-100B within 24 h after acute cerebral infarction in 70 patients and 40 normal individuals. Results The levels of serum OX-LDL,S-100B in the patients with acute cerebral infarction were significantly higher than those in the normal controls（P〈0.01）. The levels of serum OX-LDL, S100B in the patients were （615.9 ± 197.6） μg/L, （0. 884± 0. 594）μg/L respectively,while levels in the controls were （158. 6±68.4）μg/L, （0. 065±0. 02）μg/L respectively. Serum OX-LDL was positively correlated with S-100B （r= 0. 536, P〈0.01）. The results showed the concentration of serum OX-LDL,S-100B were closely associated with the degree of acute cerebral infarction. Conclusion The concentration of serum OX-LDL,S-100B might be available index for the severity of acute cerebral infarction o