异维A酸软胶囊联合克拉霉素治疗中、重度痤疮的疗效

目的 评价异维A酸软胶囊联合克拉霉素治疗中、重度痤疮的疗效。方法 选取2020年8月-2021年5月广西桂平市人民医院皮肤科收治的128例中、重度痤疮患者为研究对象，采用随机数字表法分为观察组与对照组，每组64例。对照组给予克拉霉素治疗，观察组在对照组基础上联合异维A酸软胶囊治疗，比较两组痤疮综合分级系统（GAGS）评分、临床疗效、性激素水平孕酮（P）、睾酮（T）、雌二醇（E2）]、不良反应发生率与复发率。结果 两组治疗后GAGS评分低于治疗前，且观察组低于对照组，差异有统计学意义（P＜0.05）；观察组治疗总有效率为93.75%，高于对照组的81.25%，差异有统计学意义（P＜0.05）；两组治疗后P、T水平低于治疗前，E2水平高于治疗前，且观察组P、T水平低于对照组，E2水平高于对照组，差异有统计学意义（P＜0.05）；两组不良反应发生率比较，差异无统计学意义（P＞0.05）；治疗6个月后，观察组总复发率为1.56%，低于对照组的9.38%，差异有统计学意义（P＜0.05）。结论 异维A酸软胶囊联合克拉霉素治疗中、重度痤疮的疗效确切，可有效改善中、重度痤疮患者临床症状，调节体内性激素水平，降低复发风险，且不良反应少。

Effect of Isotretinoin Soft Capsule Combined with Clarithromycin on Moderate and Severe Acne

Objective To evaluate the efficacy of isotretinoin soft capsule combined with clarithromycin in the treatment of moderate and severe acne. Methods A total of 128 patients with moderate and severe acne admitted to the Department of Dermatology of Guangxi Guiping People''s Hospital from August 2020 to May 2021 were selected as the research objects. They were divided into observation group and control group by random number table method, with 64 cases in each group. The control group was treated with clarithromycin, and the observation group was treated with isotretinoin soft capsule on the basis of the control group. The Global Acne Grading System (GAGS) score, clinical effica, sex hormone levels progesterone (P), testosterone (T), estradiol (E2)], incidence of adverse reactions and recurrence rate were compared between the two groups. Results The GAGS score of the two groups after treatment was lower than that before treatment, and the observation group was lower than the control group, the differencewas statistically significant(P<0.05). The total effectiverate of the observation group was 93.75%, which was higher than 81.25% of the control group, and the difference wasstatistically significant P<0.05). After treatment, the levels of P and T in the two groups were lower than those before treatment, and the level of E2 was higher than that before treatment, meanwhile the levels of P and T in the observation group were lower than those in the control group, and the level of E2 was higher than that in the control group, the differene was statistically signifiant (P<0.05). There was no significan differnce in the incidence of adverse reactions between the two groups (P>0.05). After 6 months of treatment, the total recurrence rate of the observation group was 1.56%, which was lower than 9.38% of the control group, and the differencewas statistically significant(P<0.05). Conclusion Isotretinoin soft capsule combined with clarithromycin is effective in the treatment of moderate and severe acne, which can effectivelyimprove the clinical symptoms of patients with moderate and severe acne, regulate the level of sex hormones in vivo, reduce the risk of recurrence, and have less adverse reactions.