厄贝沙坦和咪哒普利抑制自发性高血压大鼠阻力血管重塑的实验研究

目的 :探讨厄贝沙坦、咪哒普利对自发性高血压大鼠 (SHR)阻力血管重塑的抑制作用并比较二者的作用效果。方法 :选用 1 3周龄的SHR30只、WKY大鼠 1 0只随机分为四组 :SHR组 ,厄贝沙坦组 ,咪哒普利组 ,WKY组。实验期 1 5周。观察指标 :血压 ,肠系膜动脉中膜厚度 /管腔半径、中膜面积 /腔面积、管腔半径 /血管半径 ,肠系膜动脉的形态学 (光镜、电镜 ) ,血浆、肠系膜动脉AngⅡ浓度。 结果 :咪哒普利组、厄贝沙坦组血压控制良好 ,肠系膜动脉重塑的各项指标改善 ,在这些指标上二者无显著性差异 ;肠系膜动脉结构改变尤其是纤维化均减轻 ,咪哒普利组减轻更明显。结论 :咪哒普利、厄贝沙坦不仅能良好地控制血压而且可以抑制自发性高血压大鼠阻力血管重塑 ;在防止肠系膜动脉结构改变尤其是纤维化方面 ,咪哒普利作用优越于厄贝沙坦。

Experimental Study of Imidapril and Irbesartan Inhibitoring Resistance Vessel Remodeling in Spontaneously Hypertension Rats

To research inhibiting effect of Imidapril and Irbesa rtan on resistance vessel remodeling in spontaneously hypertension rats and comp are their effects.Method: Thirty 13 weeks old spontaneously hypertension rats were randomly divide into three groups:SHR positive control group,Imidapril treating group(3 mg/kg in everyclay),Irbesartan treating group(50 mg/kg in everyclay).Te n homogenous Wistar Kyoto rats were selected as normal control g roup.Monitoring blood pressure of rats periodically;After 15 weeks,putting all r ats to death.Specimen of the second grade branch of mesenteric arteries were obs erved by light and transmission electron microscope and media thickness to lumen radius ratio,media to lumen area ratio were calculated by a computer image anal ysis system;AngⅡ level of plasma,mesenteric arteries were measured by radioimmu noassay.Results: Blood pressure and media thickness to lumen radius rati o,media to lumen area ratio,lumen to vessel radius ratio of Imidapril group and Irbesartan group were lower than those of SHR group.Imidapril group and Irbesart an group had no difference in these indexes;AngⅡ level of plasma,mesenteric art eries in SHR group was same or lower than that in WKY group and that of Irbesart an group was higher and that of Imidapril was lower;mesenteric arteries modulati on in structure especially fibrosis were slighter in Imidapril group and Irbesar tan group.Furthermore,modulation of Imidapril group was slighter than that of Ir besartan group.Conclusion: Not only Imidapril and Irbesartan could controlled b lood pressure well but also they could inhibit mesenteric arteries remodeling in SHR;Imidapril was better than Irbesartan in preventing left ventricle and mesen teric arteries from modulation in structure especially fibrosis.