| Puerarin accelerates neural regeneration after sciatic nerve injury |
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| 作者姓名： | Minfei Wu Guanjie Zhao Xiaoyu Yang Chuangang Peng Jianwu Zhao Jun Liu Rui Li Zhongli Gao |
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| 作者单位： | [1]Department of Orthopedics, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China [2]Department of Nephropathy, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China [3]Hand ＆ Foot Surgery and Reparative ＆ Reconstruction Surgery Center, the Second Hospital of Jilin University, Changchun, Jilin Province, China |
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| 摘 要： | Puerarin is a natural isoflavone isolated from plants of the genus Pueraria and functions as a protector against cerebral ischemia. We hypothesized that puerarin can be involved in the repair of peripheral nerve injuries. To test this hypothesis, doses of 10, 5, or 2.5 mg/kg per day puerarin(8-(β-D-Glucopyranosyl-7-hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one) were injected intraperitoneally into mouse models of sciatic nerve injury. Puerarin at the middle and high doses significantly up-regulated the expression of growth-associated protein 43 in the L4–6 segments of the spinal cord from mice at 1, 2, and 4 weeks after modeling, and reduced the atrophy of the triceps surae on the affected side and promoted the regeneration of nerve fibers of the damaged spinal cord at 8 weeks after injury. We conclude that puerarin exerts an ongoing role to activate growth-associated protein 43 in the corresponding segment of the spinal cord after sciatic nerve injury, thus contributing to neural regeneration after sciatic nerve injuries.
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| 关 键 词： | 神经再生 坐骨神经 葛根素 周围神经损伤 生长相关蛋白 苯并吡喃 羟基苯基 职能分离 |
Puerarin accelerates neural regeneration after sciatic nerve in）ury |
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| Minfei Wu,Guanjie Zhao,Xiaoyu Yang,Chuangang Peng,Jianwu Zhao,Jun Liu,Rui Li,Zhongli Gao.Puerarin accelerates neural regeneration after sciatic nerve injury[J].Neural Regeneration Research,2014,9(6):589-593. |
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| Authors: | Minfei Wu Guanjie Zhao Xiaoyu Yang Chuangang Peng Jianwu Zhao Jun Liu Rui Li Zhongli Gao |
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| Institution: | 1.Department of Orthopedics, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China;2.Department of Nephropathy, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China;3.Hand & Foot Surgery and Reparative & Reconstruction Surgery Center, the Second Hospital of Jilin University, Changchun, Jilin Province, China |
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| Abstract: | Puerarin is a natural isoflavone isolated from plants of the genus Pueraria and functions as a protector against cerebral ischemia. We hypothesized that puerarin can be involved in the repair of peripheral nerve injuries. To test this hypothesis, doses of 10, 5, or 2.5 mg/kg per day puerarin (8-(β-D-Glucopyranosyl-7-hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one) were injected intraperitoneally into mouse models of sciatic nerve injury. Puerarin at the middle and high doses significantly up-regulated the expression of growth-associated protein 43 in the L4–6 segments of the spinal cord from mice at 1, 2, and 4 weeks after modeling, and reduced the atrophy of the triceps surae on the affected side and promoted the regeneration of nerve fibers of the damaged spinal cord at 8 weeks after injury. We conclude that puerarin exerts an ongoing role to activate growth-associated protein 43 in the corresponding segment of the spinal cord after sciatic nerve injury, thus contributing to neural regeneration after sciatic nerve injuries. |
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| Keywords: | nerve regeneration peripheral nerve injury puerarin growth-associated protein 43 sci-atic nerve repair NSFC grant neural regeneration 2014-02-26 |
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