CD49d单抗加rhG-CSF动员外周血干细胞对造血重建的影响 |
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引用本文: | 杜遵民,刘传方,唐天华,张玉昆,张立成,李大鹏.CD49d单抗加rhG-CSF动员外周血干细胞对造血重建的影响[J].实用医药杂志(山东),2004,21(7):624-626. |
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作者姓名: | 杜遵民 刘传方 唐天华 张玉昆 张立成 李大鹏 |
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作者单位: | 88医院血液科 山东泰安271000
(杜遵民,张立成),山东大学齐鲁医院血液科 山东济南250012
(刘传方),山东省医学科学院基础所 山东济南250062
(唐天华,张玉昆),88医院血液科 山东泰安271000(李大鹏) |
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基金项目: | 济南军区"十五"重点科研项目(02Z49) |
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摘 要: | 目的探讨抗CD49d单克隆抗体穴McAb雪联用重组人粒细胞集落刺激因子穴rhG-CSF雪动员的外周血干细胞对造血重建的影响。方法经放、化疗预处理的BALB/c小鼠,分别接受经rhG-CSF(实验1组)、抗CD49dMcAb(实验2组)、抗CD49dMcAb联合rhG-CSF(实验3组)动员的同系小鼠的外周血干细胞移植,观察受体小鼠的4周存活率及外周血白细胞(WBC)、骨髓单核细胞(BMNC),粒细胞巨噬细胞集落形成单位(CFU-GM)及脾集落形成单位(CFU-S)等指标。结果实验3组小鼠的4周存活率、WBC、BMNC,CFU-GM、CFU-S数均明显高于实验1和2组,具有显著性差异(P<0.05或P<0.01)。结论抗CD49dMcAb联合rhG-CSF应用能协同动员小鼠外周血干细胞,并能成功重建同系小鼠的造血功能。
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关 键 词: | 抗CD49d单克隆抗体 粒细胞集落刺激因子 外周血干细胞移植 造血重建 |
修稿时间: | 2004年4月27日 |
Experimental study on hematopoietic reconstruction effects of peripheral blood stem cells mobilized by anti-CD49d monoclonal antibody plus rhG-CSF in mice |
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Abstract: | Objective To study the hematopoietic reconstruction effects of peripheral blood stem cell(PBSC)mobilized by anti-CD49d monoclonal antibody(McAb)with recombinant human granulocyte colony-stimulating factor(rhG-CSF)in mice.Methods BALB/c mice pre-conditioned with chemotherapy and total body irradiation were transplanted with PBSCs from rhG-CSF-mobilized mice(experimental group1),with PBSCs from anti-CD49d McAb-mobilized mice(experimental group2),with PBSCs from above mobilized mice(experimental group3).The white blood cells(WBC)count,four-week survival rate,bone marrow nuclear cells(BMNC),granulocyte-macrophage colony-forming units(CFU-GM),colony-forming unit of spleen(CFU-S)were observed.Results Survival rate,and WBC,BMNC,CFU-GM,CFU-S counts were significantly higher in experimental group3than those of the experimental group1,experimental group2(P<0.01or P<0.05).Conclusions Anti-CD49d McAb and rhG-CSF may synergetically mobilize PBSC in mice.PBSCs mobilized by anti-CD49d McAb combined with rhG-CSF could effectively reconstruct hematopoiesis in mice. |
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Keywords: | Anti-CD49d monoclonal antibody Granulocyte-colony stimulating factor Peripheral blood stem cell transplantation Hematopoiesis restruction |
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