| 山西狭苞橐吾化学成分研究 |
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| 引用本文： | 薛慧清,马雪梅,魏小宁,武水仙,汪汉卿,. 山西狭苞橐吾化学成分研究[J]. 中国中药杂志, 2007, 32(11): 1044-1047 |
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| 作者姓名： | 薛慧清 马雪梅 魏小宁 武水仙 汪汉卿 |
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| 作者单位： | 1. 中国科学院,兰州化学物理研究所,OSSO国家重点实验室,甘肃,兰州,730000;中国科学院,研究生院,北京,100039;山西中医学院,实验中心,山西,太原,030024
2. 中国科学院,兰州化学物理研究所,OSSO国家重点实验室,甘肃,兰州,730000 |
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| 摘 要： | 目的：研究产自山西的狭苞橐吾Ligularia intermedia的化学成分。方法：用硅胶柱色谱(CC)、制备薄层色谱(PTLC)、重结晶等方法进行分离纯化,经现代波谱技术：红外、质谱、一维和二维核磁共振谱及X-射线单晶衍射等方法对化合物进行结构鉴定。结果：分离鉴定了9个化合物,分别为：8β-hydroxyeremophil-7(11)-ene-12,8α(4β,6α)-diolide(1),8β-methoxyeremophil-7(11) -ene-12,8α(4β,6α)-diolide(2),蜂斗菜素(petasin,3),异蜂斗菜素(isopetasin,4),liguhodgsonal(5),ligudentatol(6),ligujapone(7),羽扇豆醇(lupeol,8)和羽扇豆醇棕榈酸酯(lupeol palmitate,9)。结论：其中化合物2,3,4,6,7,9为首次从狭苞橐吾中获得。
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| 关 键 词： | 狭苞橐吾 化学成分 倍半萜 |
| 文章编号： | 1001-5302（2007）11-1044-04 |
| 收稿时间： | 2006-08-11 |
| 修稿时间： | 2006-08-11 |
Study on chemical constiuents from Ligularia intermedia of Shanxi |
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| XUE Hui-qing;;; MA Xue-mei; WEI Xiao-ning; WU Sui-xian; WANG Han-qing. Study on chemical constiuents from Ligularia intermedia of Shanxi[J]. China Journal of Chinese Materia Medica, 2007, 32(11): 1044-1047 |
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| Authors: | XUE Hui-qing MA Xue-mei WEI Xiao-ning WU Sui-xian WANG Han-qing |
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| Affiliation: | 1. Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China; 2. Graduate University of Chinese Academy of Sciences, Beijing 100039, China; 3. Shanxi College of Traditional Chinese Medicine, Taiyuan 030024, China |
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| Abstract: | OBJECTIVE: To study the chemical constituents of Ligularia intermedia of Shanxi. METHOD: The compounds were isolated by column chromatography on silica gel and preparative TLC. The structures were identified by IR, MS, 1D/2DNMR spectral data and X-ray single crystal diffraction and other methods1. RESULT: Nine compound were isolated and identified as 8beta-hydroxyeremophil-7(11)-ene-12, 8alpha(4beta, 6alpha)-diolide (1), 8beta-methoxyeremophil-7(11)-ene-12, 8alpha(4beta, 6alpha)-diolide (2), petasin (3), isopetasin (4), liguhodgsonal (5), ligudentatol (6), ligujapone (7), lupeol (8) and lupeol palmitate (9). CONCLUSION: Compounds 2, 3, 4, 6, 7 and 9 were isolated from the plant for the first time. |
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| Keywords: | Ligularia intermedia chemical constituents sesquiterpenes |
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