110例心肌梗死患者载脂蛋白E基因多态性

为探讨载脂蛋白Ｅ基因型和心肌梗死之间的关系，采用聚合酶链反应－限制性片长多态性分析１１０例心肌梗死患者和１３１例健康对照者的载脂蛋白Ｅ基因型及其在两组人群中的不同分布。结果发现对照组和心肌梗死组Ｅ３／３基因型发生频率最高，占整个样本的７０％，含载脂蛋白Ｅ３的杂合子居中，占整个样本的２５．３％，Ｅ４／４基因型的发生频率最低。

Apolipoprotein E Polymorphism in 110 Patients with Myocardial Infarction

Aim To study the relation between apolipoprotein E polymorphism and myocardial infarction. Methods 110 patients with myocardial infarction and 131 normals were enrolled and blood samples were collected. Their apoE genotyping were performed by polymerase chain reaction (PCR). Results Both in cases and controls, the allelic frequency of E3/3 was highest, reaching 70.1 percentage of whole volume, hemozygote of apo E3 was moderate, and homozygote E4/4 was lowest. The frequencies of E3/4 and E4/4 was significantly high in patients with myocardial infarction compared with controls (P<0.01). It was found primarily that the age of first acute myocardial infarction was earlier in the carriers of E4. Conclusions apo E4 is an important genetic mark of the patients with myocardial infaction. The age of first acute myocardial infarction was earlier in the carriers of E4.