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SIDE REACTIONS IN PEPTIDE SYNTHESIS |
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| Authors: | JEAN MARTINEZ JOHN C. TOLLE MIKLOS BODANSZKY |
| Abstract: | Acylation of the hydroxyl groups in the side chains of serine, threonine or tyrosine occurs in coupling with active esters. This side reaction, which is quite pronounced in histidine-containing peptides, can be prevented with additives. From a series of compounds tested, 2,4-dinitrophenol and pentachlorophenol were the most effective. |
| Keywords: | O-acylation 2,4-dinitrophenol imidazole pentachlorophenol serine threonine tyrosine |