甲磺酸多拉司琼与盐酸格拉司琼预防化疗性呕吐的临床对比研究

目的 对比甲磺酸多拉司琼与盐酸格拉司琼预防化疗性呕吐的临床效果.方法 选取0018年1月至0000年1月在我院行化疗治疗的40例恶性肿瘤患者,随机分为两组各00例.化疗前,对照组采用盐酸格拉司琼预防化疗性呕吐,研究组采用甲磺酸多拉司琼预防化疗性呕吐.比较两组用药过程中的不良反应发生率,以及化疗结束后的急性呕吐、延迟性呕...

Clinical Comparative Study of Dolasetron Mesylate Versus Granisetron Hydrochloride in the Prevention of Chemotherapy-Induced Vomiting

Objective To compare the clinical effects of dolasetron mesylate versus granisetron hydrochloride in the prevention of chemotherapy-induced vomiting.Methods 40 patients with malignant tumor who received chemotherapy in our hospital from January 2018 to January 2020 were selected and randomly divided into two groups,with 20 cases in each group.Before chemotherapy,granisetron hydrochloride was used in the control group to prevent chemotherapy-induced vomiting,while dolasetron mesylate was used in the study group to prevent chemotherapy-induced vomiting.The incidence of adverse reactions during the course of medication,and the incidences of acute vomiting,delayed vomiting and nausea after the end of chemotherapy were compared between the two groups.Results During the course of medication,no obvious adverse reaction occurred in both groups.After the end of chemotherapy,the incidences of acute vomiting,delayed vomiting and nausea in the study group were 10.00%,5.00%and 10.00%respectively,significantly lower than 40.00%,30.00%and45.00%in the control group,respectively,with statistically significant differences(all P<0.05).Conclusions Dolasetron mesylate has significant effect in the prevention of chemotherapy-induced vomiting,and can effectively reduce the incidences of acute vomiting,delayed vomiting and nausea,with high safety.