恢复期老年抑郁症伴轻度认知障碍患者执行功能及事件相关电位的关系研究

目的研究恢复期老年抑郁症伴轻度认知障碍患者执行功能及事件相关电位的关系。方法选取2017年1月至2019年12月期间我院收治的恢复期老年抑郁症患者78例,采用MoCA量表评估其认知功能,将认知功能正常(MoCA评分≥26分)的58例患者纳入对照组,将轻度认知功能障碍(15≤MoCA评分<26分)的20例患者纳入观察组,测定两组患者事件相关电位及执行功能,分析执行功能与事件相关电位的相关性。结果观察组P300波幅低于对照组,P300潜伏期长于对照组,错误应答数、持续性错误数、持续性反应数均高于对照组(P<0.05)。Pearson相关性分析显示,P300潜伏期与错误应答数、持续性错误数、持续性反应数呈正相关(r>0,P<0.05);P300波幅与错误应答数、持续性错误数、持续性反应数呈负相关(r<0,P<0.05)。结论恢复期老年抑郁症伴轻度认知障碍患者执行功能与事件相关电位关系密切,可用事件相关电位来判断患者的执行功能障碍。

Study on the Correlation between Executive Function and Event-Related Potential in Elderly Patients with Depression in Recovery Period and Mild Cognitive Impairment

Objective To study the correlation between executive function and event-related potential in elderly patients with depression in recovery period and mild cognitive impairment. Methods 78 elderly patients with depression in recovery period admitted to our hospital from January 2017 to December 2019 were selected. The Mo CA scale was used to evaluate the cognitive function. 58 patients with normal cognitive function(MoCA score ≥26 points) were set as the control group, and 20 patients with mild cognitive impairment(15 points≤ MoCA score <26 points) were set as the observation group. The event-related potential and executive function were detected, and the correlation between executive function and event-related potential was analyzed. Results The P300 amplitude in the observation group was lower than that in the control group, the P300 latency was longer than that in the control group, and the number of wrong answers, the number of persistent errors and the number of persistent reactions were higher than those in the control group(P <0.05). Pearson correlation analysis showed that the P300 latency was positively correlated with the number of wrong answers, the number of persistent errors and the number of persistent responses(r>0, P <0.05);The P300 amplitude was negatively correlated with the number of wrong answers, the number of persistent errors and the number of persistent responses(r<0, P <0.05). Conclusions Executive function is closely correlated with event-related potential in elderly patients with depression in recovery period and mild cognitive impairment, so event-related potential can be used to judge patients’ executive dysfunction.