| 新型纳米结构脂质载体系统的研究进展 |
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| 引用本文： | 刘凯,孙进,何仲贵.新型纳米结构脂质载体系统的研究进展[J].沈阳药科大学学报,2008,25(3):236-242. |
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| 作者姓名： | 刘凯 孙进 何仲贵 |
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| 作者单位： | 沈阳药科大学,药学院,辽宁,沈阳,110016 |
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| 摘 要： | 目的介绍新型的纳米结构脂质载体系统的研究进展,为其研究和应用提供参考。方法查阅相关文献33篇,进行整理和归纳。结果新型的纳米结构脂质载体能够克服固体脂质纳米粒的一些不足,并具有独特的结构特征,药物的包封机理和释放特征。结论纳米结构脂质载体作为药物传递系统的一种新剂型,具有广阔的发展前景。
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| 关 键 词： | 纳米结构脂质载体 固体脂质纳米粒 结构特征 包封 释放 应用 |
| 文章编号： | 1006-2858（2008）03-0236-07 |
| 收稿时间： | 2006-07-08 |
| 修稿时间： | 2006年7月8日 |
Development on novel nanostructured lipid carriers |
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| LIU Kai,SUN Jin,HE Zhong-gui.Development on novel nanostructured lipid carriers[J].Journal of Shenyang Pharmaceutical University,2008,25(3):236-242. |
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| Authors: | LIU Kai SUN Jin HE Zhong-gui |
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| Institution: | (School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, China) |
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| Abstract: | Objective To review the study on novel nanostructured lipid carriers (NLC) and provide a reference for the further research and development of NLC. Methods The structure features, production methods, stability, drug incorporation and drug release mechanisms, application of NLC were introduced on the basis of related references. Results Novel NLC could overcome the potential drawbacks of solid lipid nanoparticles (SLN) and possess the particular structure features, drug incorporation mechanisms and drug release characters. Conclusion As a new dosage form of drug delivery systems, NLC has an exciting prospect in pharmaceutics. |
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| Keywords: | nanostructured lipid carriers solid lipid nanoparticles structure features incorporation release application |
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