新生儿急性细菌性结膜炎病原菌及药物敏感性分析

目的探讨近年来新生儿急性细菌性结膜炎主要致病菌的特点及药物敏感试验结果,为临床寻找该疾病的有效抗生素和合理用药提供科学依据。方法对近5年临床诊断为新生儿急性细菌性结膜炎的82例患儿 (129只眼),进行结膜囊分泌物的细菌培养和种类鉴定,并对阳性培养菌株进行药物敏感试验和分析。结果新生儿急性细菌性结膜炎的细菌平均检出率为76．0％。不同年份的细菌检出率变化不明显(x2=0．80,P>0．05)。根据培养结果,新生儿急性细菌性结膜炎的致病菌,由以往金黄色葡萄球菌、草绿色链球菌为主,转变为以淋球菌、表皮葡萄球菌和腐生葡萄球菌为主。大多数细菌对环丙沙星敏感,对氯霉素耐药。结论新生儿急性细菌性结膜炎的致病菌株同以往相比较发生了较大的改变,其耐药性也发生了相应的改变。

The vicissitudes of bacterial culture results and antibiotic sensitivity of the pathogenic bacteria in acute neonatal conjunctivitis

Objective To research the vicissitudes of positive rate of bacterial culture and drug sensitivity test of secretion specimens from the inferior palpebral conjunctival surface of neonats with acute bacterial conjunctivitis during 1999-2004 and search for sensitive antibiotics for its treatment. Methods secretion specimens were taken from 129 eyes of 82 cases with clinically diagnosed the acute bacterial neonatal conjunctivitis for bacterial culture, and drug sensitivity test was carried out for the positive specimens. Results Bacterial positive rate was 76% with insignificant changes among the different years. The main bacteria of acute neonatal conjunctivitis was changed from staphylococcus aureus, streptococcus viridans to staphylococcus epidermidais staphylococcus saprophyticus and neisseria gonor-rhoeae. Ciprofloxacin was the most sensitive antibiotics. Most bacteria were resistant to chloromycetin. Conclusion The results of bacterial culture combined with drug sensitivity test of secretion specimens from the inferior palpebral conjunctival surface is different from that of before, and its tolerance is changing at the same time.