Function and recruitment of mucosal regulatory T cells in human chronic Helicobacter pylori infection and gastric adenocarcinoma |
| |
Authors: | Enarsson Karin Lundgren Anna Kindlund Bert Hermansson Mikael Roncador Giovanna Banham Alison H Lundin B Samuel Quiding-Järbrink Marianne |
| |
Affiliation: | Inst. of Biomedicine, Dept. of Microbiology and Immunology and G?teborg University Vaccine Research Institute GUVAX, G?teborg, Sweden. |
| |
Abstract: | CD4(+)CD25(high) FOXP3-expressing regulatory T cells (Treg) can suppress immune responses to infections and tumors, thereby promoting microbial persistence and tumor progression. However, little is known about the phenotype and function of human mucosal Treg. Therefore, we analyzed the suppressive activity and homing phenotype of Treg in gastric mucosa of Helicobacter pylori-infected gastric adenocarcinoma patients. We found increased numbers of CD4(+)FOXP3(+) Treg in the tumor compared to tumor-free gastric mucosa. Gastric Treg cells were able to suppress H. pylori-induced T cell proliferation and IFN-gamma production. Furthermore, gastric Treg expressed increased levels of l-selectin and CCR4, compared to non-Treg cells, suggesting that these receptors contribute to Treg recruitment. The presence of functional antigen-specific Treg in H. pylori-infected gastric mucosa supports an important role for these cells in suppression of mucosal effector T cell responses, which probably contribute to bacterial persistence and possibly also to gastric tumor progression. |
| |
Keywords: | Helicobacter pylori Regulatory T cells Human Mucosal immunity Migration |
本文献已被 ScienceDirect PubMed 等数据库收录! |