TNT作业工人和慢性乙型肝炎患者血糖和血清胆酸含量的变化

目的：探讨TNT作业工人早期肝损害健康监护指标。方法：对山东某TNT炸药厂进行劳动卫生学调查，并分析TNT作业工人与慢性乙 型肝炎患血糖和血清胆酸含量的变化。结果：车间空气TNT平均浓度超过国家最高容许浓度（MAC＝1mg/m^3），TNT作业工人皮肤TNT污染严重。TNT接触组血糖、血清总胆固醇和胆酸含量显高于对照组（P＜0．01）。慢性乙型肝炎组血糖和胆酸含量显高于对照组（P＜0．01），其血清总胆固醇含量接近对照组水平。结论：建议血糖及血清胆酸含量的变化可作为TNT作业工人早期肝损伤健康监护指标。

The Changes of theContents of Blood Sugar and Bile Acid in Serum of the Workers Exposed to Trinitrotolueneand the Patients Suffered from Chronic Hepatitis B

Objective To study indexes of health surveillance for early liver damage of the workers exposed to trinitrotoluene.Methods The inspection of occupational health were conducted in a TNT explosive plant in Shandong Province and the contents of blood sugar and bile acid in serum of the workers exposed to trinitrotoluene and the patients suffered from chronic hepatitis B were analyzed.Results The average TNT concentrations in the air of workshops were beyond the national maximum allowable concentration(MAC=1mg/m 3) and the skin of TNT exposed workers were seriously contaminated with TNT.The content of blood sugar,the contents of total cholesterol and bile acid in serum of the TNT exposed group were much higher than those for the control group (P<0 01).The content of blood sugar,the content of bile acid in serum of the chronic hepatitis B group wer much higher than those of the control group(P<0 01).The content of total cholesterol in serum of the chronic hepatitis B group almost approached the level of that of the control group.Conclusion It suggested that the changes of blood sugar and bile acid in serum of TNT exposed workers might serve as indexes of health surveillance for early liver damage induced with TNT.